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UnknownNucleolin in the cell membrane promotes Ang II-mediated VSMC phenotypic switching by regulating the AT1R internalization function : Nucleolin promotes Ang II-mediated VSMC phenotypic switching.
Not available
S-EPMC11863493 | biostudies-literature
UnknownAMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque Stability.
Not available
S-EPMC6265658 | biostudies-literature
GenomicsGLS1 governs vascular smooth muscle cell phenotypic switching and aortic dissection via glutamate metabolism
GLS1 governs vascular smooth muscle cell phenotypic switching and aortic dissection via glutamate metabolism
PRJNA1438102 | ENA
TranscriptomicsGLS1 governs vascular smooth muscle cell phenotypic switching and aortic dissection via glutamate metabolism
To evaluate the roles of glutaminase 1 (GLS1) in vascular smooth muscle cells (VSMCs) phenotypic switching and aortic dissection (AD). Integrative transcriptomic analyses were performed to identify the candidate genes involved in VSMC phenotypic switching in AD. The expression of GLS1 in VSMCs was a...
ORGANISM(S): Homo sapiens 
2026-03-20 | GSE324926 | GEO
TranscriptomicsInterleukin-11 signaling drives vascular smooth muscle phenotypic switching and contributes to aortic remodelling
RNA sequencing of primary human aortic or arterial VSMCs after stimulation with transforming growth factor beta-1 (TGFβ1) revealed marked IL11 upregulation. In vitro, IL11 stimulation of VSMCs resulted in phenotypic switching by increased ECM production and migration/invasion. Neutralizing IL11 anti...
ORGANISM(S): Homo sapiens 
2020-10-20 | GSE142417 | GEO
GenomicsSIRT7 regulates smooth muscle phenotypic switching by deacetylating SRF to repress abdominal aortic aneurysm formation
SIRT7 regulates smooth muscle phenotypic switching by deacetylating SRF to repress abdominal aortic aneurysm formation
PRJNA1283952 | ENA
GenomicsInterleukin-11 signaling drives vascular smooth muscle phenotypic switching and contributes to aortic remodelling
Interleukin-11 signaling drives vascular smooth muscle phenotypic switching and contributes to aortic remodelling
PRJNA596994 | ENA
TranscriptomicsSIRT7 regulates smooth muscle phenotypic switching by deacetylating SRF to repress abdominal aortic aneurysm formation
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease for which there are no effective pharmacological treatments. Histone deacetylases (HDACs) have gained increasing recognition as critical regulators of the pathological processes of various cardiovascular diseases. However, ...
ORGANISM(S): Mus musculus 
2026-09-15 | GSE301109 | GEO
UnknownNLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension.
Not available
S-EPMC5680591 | biostudies-literature
TranscriptomicsMicrovascular smooth muscle cells exhibit divergent phenotypic switching responses to platelet-derived growth factor and insulin-like growth factor 1
Objective: Vascular smooth muscle cell (VSMC) phenotypic switching is critical for normal vessel formation, vascular stability, and healthy brain aging. Phenotypic switching is regulated by mediators including platelet derived growth factor (PDGF)-BB, insulin-like growth factor (IGF-1), as well as t...
ORGANISM(S): Rattus norvegicus 
2025-12-09 | GSE312686 | GEO
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