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TranscriptomicsGene expression profiling of temporal lobes of wfs1 deficient mice
Aim of present study was to describe the changes induced deletion of the Wfs1 gene in the temporal lobe of mice. Mutant mice were backcrossed to two different genomic backgrounds in order to exclude confounding foreign genomic background influence. Samples from temporal lobes were analyzed by using ...
ORGANISM(S): Mus musculus 
2010-04-06 | E-GEOD-15293 | biostudies-arrayexpress
TranscriptomicsHypothalamic gene expression profile indicates a reduction in G-protein signaling in the wfs1 mutant mice
WFS1 gene is coding protein with unknown function but its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes. In the present study we aimed to find the functional networks influenced by the Wfs1 deficiency in the hypothalamus. We performed gene expression profiling ...
ORGANISM(S): Mus musculus 
2011-11-02 | E-GEOD-33372 | biostudies-arrayexpress
TranscriptomicsSilencing of the WFS1 gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage.
The gene WFS1 encodes a protein with unknown function although its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes. In the present study, we aimed to find the functional networks influenced by the time-dependent silencing of WFS1 in HEK cells. We performed whole ...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-40585 | biostudies-arrayexpress
ProteomicsWfs1-deficient mouse muscle LC–MSMS
This dataset reports the analysis of Wfs1-deficient mouse heart, musculus soleus, and white part of musculus rectus femoris by liquid chromatography/tandem mass spectrometry.
ORGANISM(S): Mus musculus (Mouse) 
2018-11-04 | PXD011019 | Pride
Wolfram syndrome  wfs1  myocardium Skeletal muscle  animal proteomics 
TranscriptomicsEffect of chronic valproic acid treatment on hepatic gene expression profile in Wfs1 knockout mouse.
Aim of the present study was to compare the effect of chronic VPA treatment in wild type and Wfs1 knockout mice on hepatic gene expression profile. Wild type, Wfs1 heterozygous and homozygous mice were treated with VPA for three months (300 mg/kg i.p. daily) and gene expression profiles in liver wer...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-55143 | biostudies-arrayexpress
GenomicsNext Generation Sequencing of WFS1 gene
WFS1 gene associated diabetes phenotypes and identification of a founder mutation in Southern India.
PRJEB48305 | ENA
TranscriptomicsReduced insulin secretion in WFS1-deficient mice may be related to downregulation of Trpm5
Wolfram syndrome, an autosomal recessive disorder characterized by juvenile-onset diabetes mellitus and optic atrophy, is caused by mutations in the WFS1 gene. WFS1 encodes an endoplasmic reticulum resident transmembrane protein. The Wfs1-null mice exhibit progressive insulin deficiency and diabetes...
ORGANISM(S): Mus musculus 
2015-02-14 | E-GEOD-65929 | biostudies-arrayexpress
GenomicsExpression profiles in pancreatic islets from Wfs1-deficient mice
Expression profiles in pancreatic islets from Wfs1-deficient mice
PRJNA1076885 | ENA
TranscriptomicsHippocampus and hypothalamus RNA-sequencing of WFS1-deficient mice [hypothalamus]
Wolfram syndrome is caused by mutations in the WFS1 gene. WFS1 protein dysfunction results in a range of neuroendocrine syndromes and is mostly characterized by juvenile-onset diabetes mellitus and optic atrophy. WFS1 has been shown to participate in membrane trafficking, protein processing and Ca2+...
ORGANISM(S): Mus musculus 
2017-12-01 | GSE102624 | GEO
TranscriptomicsHippocampus and hypothalamus RNA-sequencing of WFS1-deficient mice [hippocampus]
Wolfram syndrome is caused by mutations in the WFS1 gene. WFS1 protein dysfunction results in a range of neuroendocrine syndromes and is mostly characterized by juvenile-onset diabetes mellitus and optic atrophy. WFS1 has been shown to participate in membrane trafficking, protein processing and Ca2+...
ORGANISM(S): Mus musculus 
2017-12-01 | GSE102623 | GEO
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