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MetabolomicsHuman Archaeological Dentin as Source of Polar and Less Polar Metabolites for Untargeted Metabolomic Research: The Case of Yersinia pestis
Metabolomic approaches, such as in clinical applications of living individuals, have shown potential use for solving questions regarding the past when applied to archaeological material. Here, we study for the first time the potential of this Omic approach as applied to metabolites extracted from ar...
2024-03-15 | MTBLS7394 | MetaboLights
TranscriptomicsRole of the Yersinia pestis Virulence Plasmid in Evading a Protective Polymorphonuclear Leukocyte Response During the Early Stages of Bubonic Plague
A delay in the mammalian inflammatory response is a prominent feature of infection with Yersinia pestis, the agent of bubonic and pneumonic plague. Y. pestis factors have been identified that either do not stimulate a normal inflammatory response, or actively suppress it. Prominent among these are c...
ORGANISM(S): Rattus norvegicus 
2010-12-07 | E-GEOD-22299 | biostudies-arrayexpress
no omics definedTranscription profiling of Yersinia pestis wild type and phoP deletion strains
Microarrays were used to identify Y. pestis genes that are transcriptional targets of phoP. RNA samples were isolated from cultures of two isogenic Y. pestis strains, one carrying wild-type phoP (KIM6+) and the other carrying a deletion within phoP (KIM6+phoP(delta)), and their gene expression prof...
ORGANISM(S): Yersinia pestis 
2006-07-01 | E-MEXP-713 | biostudies-arrayexpress
TranscriptomicsPhenotypic and transcriptional analysis of the osmotic regulator OmpR in Yersinia pestis
Background The osmotic regulator OmpR in Escherichia coli regulates differentially the expression of major porin proteins OmpF and OmpC. In Yersinia enterocolitica and Y. pseudotuberculosis, OmpR is required for both virulence and survival within macrophages. However, the phenotypic and regulatory r...
ORGANISM(S): Yersinia pestis 
2011-10-23 | E-GEOD-26601 | biostudies-arrayexpress
TranscriptomicsPreadaptation of Yersinia pestis to resist mammalian innate immunity during transit through the flea vector
Yersinia pestis, the agent of plague, is transmitted to mammals by infected fleas. Y. pestis exhibits a distinct life stage in the flea, where it grows in the form of a cohesive biofilm that promotes transmission. After transmission, the temperature shift to 37°C induces many known virulence factors...
ORGANISM(S): Yersinia pestis 
2010-04-06 | E-GEOD-16493 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Yersinia pestis dam mutant that has attenuated virulence in mice
We have constructed a dam mutant of Yersinia pestis GB. In BALB/c mice inoculated subcutaneously, the median lethal dose of the mutant was at least 2000-fold higher than the wild type. Mice inoculated with sub-lethal doses of the mutant were protected against a subsequent challenge with virulent Y. ...
ORGANISM(S): Yersinia pestis 
2007-01-30 | E-BUGS-32 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of quorum sensing deficient in Yersinia pestis CO92 at 37M-BM-0C
Yersinia pestis, the etiological agent of plague, is able to sense cell density by quorum sensing. The function of quorum sensing in Y. pestis is not clear. Here, the process of quorum sensing was investigated by comparing transcript profiles when three quorum-sensing synthase genes are knocked out....
ORGANISM(S): Yersinia pestis 
2013-09-05 | E-GEOD-21911 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of luxS-null strain in Yersinia pestis CO92 at 37M-BM-0C
Yersinia pestis, the etiological agent of plague, is able to sense cell density by quorum sensing. The function of quorum sensing in Y. pestis is not clear. Here, the process of autoinducer 2 (AI-2) quorum sensing was investigated by comparing transcript profiles when luxS gene was knocked out. The ...
ORGANISM(S): Yersinia pestis 
2013-09-05 | E-GEOD-22849 | biostudies-arrayexpress
TranscriptomicsTranscription analysis of AI-2 signal add in experiment in Yersinia pestis CO92 at 37M-BM-0C
Yersinia pestis, the etiological agent of plague, is able to sense cell density by quorum sensing. The function of quorum sensing in Y. pestis is not clear. Here, the process of autoinducer-2 (AI-2) quorum sensing was investigated by comparing transcript profiles when AI-2 quorum-sensing signal is a...
ORGANISM(S): Yersinia pestis 
2013-09-05 | E-GEOD-22848 | biostudies-arrayexpress
ProteomicsPersistence of Yersinia pestis in tap water microcosm.
This study investigates the long-term persistence of Yersinia pestis in tap water microcosms at 25°C and examines its proteomic landscape and ability to cause lethal infection in a mouse model during persistence, assessing its potential risk for waterborne transmission. Five Y. pestis strains repres...
ORGANISM(S): Yersinia pestis 
2026-01-14 | PXD064839 | Pride
Culturability  proteomic adaptations  tap-water microcosm  yersinia pestis. 
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