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ProteomicsRapid Tear Proteomics via In-Capillary Digestion for Biomarker Discovery
Tear fluid is emerging as a valuable resource for biomarker discovery, but its low sample volume and dynamic composition pose significant challenges for analytical testing. Most tear proteomics studies have focused on samples collected with Schirmer strips, while capillary tube collection has receiv...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056978 | Pride
1. tear proteomics  2. tear biomarker  3. biomarker discovery  4. point-of-care testing  5. poct  6. lc-ms/ms 
ProteomicsAmplified fluorogenic immunoassay for early diagnosis and monitoring of Alzheimer’s disease from tear fluid
Accurate diagnosis of Alzheimer’s disease (AD) in its earliest stage can prevent the disease and delay the onset of symptoms by maintaining a healthy lifestyle and controlling modifiable risk factors. Therefore, more sensitive, relatively inexpensive, non-invasive, and simple screening tools are req...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042142 | Pride
Alzheimer’s disease Immunoassay Magnetic nanoparticles Polymeric nanoprobes Tear fluid 
ProteomicsEffect of acupuncture on tear proteomics in patients with video display terminal-related dry eye
In our study, the tear proteome was compared with identify possible mechanisms and biomarkers for predicting acupuncture effectiveness in VDT-related dry eye. The results showed that the Ocular Surface Disease Index (OSDI) scores were significantly different between the acupuncture group (AC group) ...
ORGANISM(S): Homo Sapiens 
PXD051759 |
ProteomicsAlterations in tear proteomes of adults with pre-diabetes and type 2 diabetes mellitus but without diabetic retinopathy
This study aims to explore the impact of type 2 diabetes mellitus (T2DM) on tear proteome, specifically investigating whether alterations occur before the development of diabetic retinopathy. Flush tear samples were collected from healthy subjects (n=13), subjects with preDM (n=16) and T2DM (n=18). ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD062366 | Pride
Tear film  type 2 diabetes mellitus  mass spectrometry  proteomics Machine learning. 
ProteomicsInvestigation of inter- and intra-day variability of tear fluid regarding flow rate, protein concentration as well as protein composition
Purpose: Determination of inter- and intra-day variations in tear flow rate, tear fluid protein concentration as well as protein composition regarding their impact for future biomarker studies.Methods: Tear fluid was collected non-invasively from 18 healthy subjects performing Schirmer tests at four...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037811 | Pride
Mass spectrometry Tear fluid Schirmer test Tear flow rate  tear volume Protein concentration 
ProteomicsPotential tear biomarkers for the early diagnosis of Parkinson's disease- A pilot study
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. The purpose of this study was to analyze the profile of the tear proteome of patients with idiopathic PD (iPD), carriers of the E46K-SNCA mutation and healthy subjects (CT) and to identify biomark...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD028811 | Pride
Biomarkers  parkinson’s disease  tear film  lysosome 
ProteomicsProteomic analysis of single tears from healthy human subjects
23 volunteers were recruited for this study. Tears were collected using microcapillary tubes (MCT). For each volunteer, a single tear sample was taken from one eye. For two of these volunteers, the procedure was performed in the morning (9-10 AM) and in the afternoon (5-6 PM) on the same day, once a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-06-25 | MSV000087703 | MassIVE
ProteomicsSystematic Investigation of Targeted Analysis of Metabolites and Proteins in Tear Fluid
Since the sampling of tear fluid seems rather variable we sought to evaluate a protocol for combined metabolomic and proteomic analyses with regard to clinical applicability. Tear fluid was taken from twelve human volunteers at different time points using specially designed Schirmer strips. Followin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD008536 | Pride
Tear fluid 
ProteomicsPrecision in Tear Fluid Biomarker Discovery: Quantitative Proteomic Profiling of Small-Volume, Individual Samples Using Capillary Tube Collection
Tear fluid, a complex biofluid that contains thousands of proteins and can be collected non-invasively, has emerged as a promising source of biomarkers for ocular and systemic health. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is currently the primary method for discovering novel biom...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060101 | Pride
1. tear proteomics  2. tear biomarker  3. biomarker discovery  4. capillary collection  5. lc-ms/ms 
ProteomicsHuman tear (Diabetic macular edema), LC-MSMS
Tear proteome changes in diabetic macular edema with treatment. The constitution of tear protein change was assessed for difference in treatment response
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD061821 | Pride
Lc-msms Diabetic macular edema Human tear 
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