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MetabolomicsPla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis

Bone homeostasis mainly depends on the equilibrium of osteoclasts and osteoblasts, overactivated osteoclasts play a pivotal role in the progression of osteoporosis. Here, we revealed that Pla2g7 (phospholipase A2 group VII) was positively correlated with bone resorption in clinic. By single-cell ...

2025-10-30 | MTBLS13141 | MetaboLights
MetabolomicsMetabonomic analysis of human and 12 kinds of livestock mature milk

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...

2023-08-21 | MTBLS6777 | MetaboLights
MetabolomicsAn Evolutionarily Conserved Metabolite Inhibits Biofilm Formation in Escherichia coli K-12
Methylerythritol cyclodiphosphate (MEcPP) is an intermediate in the biosynthesis of isoprenoids in plant plastids and in bacteria, and acts as a stress signal in plants. Here, we show that MEcPP regulates biofilm formation in Escherichia coli K-12 MG1655. Increased MEcPP levels, triggered by genetic...
2024-11-01 | MTBLS2240 | MetaboLights
MetabolomicsComparing Campylobacter jejuni to three other enteric pathogens in OligoMM 12 mice reveals pathogen-specific host and microbiota responses
Campylobacter jejuni, non-typhoidal Salmonella spp., Listeria monocytogenes and enteropathogenic/enterohemorrhagic Escherichia coli (EPEC/EHEC) are leading causes of food-borne illness worldwide. Citrobacter rodentium has been used to model EPEC and EHEC infection ...
2025-02-25 | MTBLS11078 | MetaboLights
MetabolomicsM12-24 metabolome of dairy cow

This study conducted non-targeted metabolomic analysis on rumen fluid from 24 dairy cows fed with M12 additive, aiming to comprehensively profile changes in endogenous metabolites and elucidate the mechanism by which M12 modulates rumen function.

2025-10-21 | MTBLS12930 | MetaboLights
MetabolomicsCXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
Kidney injury is a common complication of severe disease. Here, we report that injuries of the zebrafish embryonal kidney are rapidly repaired by a migratory response in 2-, but not in 1-day-old embryos. Gene expression profiles between these two developmental stages identify cxcl12a and myca as can...
2018-10-11 | MTBLS723 | MetaboLights
MetabolomicsC2C12 cell line knock out SCD1 or SCD2

Lipidomic profiling was performed to compare control, SCD1-knockout, and SCD2-knockout C2C12 cells under standard culture conditions. Cell pellets were collected from routinely cultured cells, rapidly frozen, and stored at −80°C prior to lipid extraction and LC–MS/MS analysis. The study aimed to ...

2026-06-23 | MTBLS14693 | MetaboLights
MetabolomicsMucosal-Associated-Invariant-T (MAIT) cells stimulated with IL-12/IL-12, anti-CD3/CD28 or both for 16 hours
Not available
ORGANISM(S): Homo sapiens 
ST001653 | MetabolomicsWorkbench
MetabolomicsMycelium of Diaporthe nobilis treated with 2% cell-free supernatant (CFS) from Bacillus velezensis A4 for 12 hours

Mycelia of Diaporthe nobilis(50 mg) treated with CFS were collected,Each sample was homogenized in 400 µL of pre-cooled 80% methanol aqueous solution containing 0.02 mg/mL L-2-chlorophenylalanine (internal standard). The mixture was ground and subjected to ultrasonication at 4 °C for 30 min. Afte...

2025-11-19 | MTBLS13351 | MetaboLights
MetabolomicsE.coli K-12 treated by IPL_analysis of organic phase
Not available
ORGANISM(S): Escherichia coli 
ST001657 | MetabolomicsWorkbench
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