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ProteomicsCoordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention
The N371 site on PKCe was mutated to TAG in an expression plasmid. This was co-transfected in a 1:1 ratio with a plasmid that encodes both an aaRS optimised to recognise AbK, and the tRNAPyl which recognises the UAG codon.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD025959 | Pride
14-3-3 pkce Mass spectrometry Phosphorylation 
TranscriptomicsRNA-sequencing of unstressed and pressure-overloaded C57 mouse hearts with single or combined ablation of PKCdelta and PKCepsilon
Combinatorial ablation of the major cardiac-expressed novel protein kinase C isoforms, PKCdelta and PKCepsilon, in murine cadiac myocytes unmasked functionally redundant growth-limiting effects of these kinases in hemodynamically stressed adult hearts and during normal embryonic cardiac development,...
ORGANISM(S): Mus musculus 
2015-04-21 | E-GEOD-62689 | biostudies-arrayexpress
ProteomicsEffects of a protein kinase C epsilon inhibitor on insulin signalling in lipid-treated HepG2 hepatocytes and glucose tolerance in fat-fed mice
Protein kinase C epsilon (PKCe) has been shown to play a causative role in the generation of glucose intolerance and insulin resistance. Tissue-specific deletion of PKC indicates multiple sites of action, highlighting the kinase as a potential target for the treatment of type 2 diabetes. CIDD-015061...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-11 | PXD054895 | Pride
Dia Mouse Swath Lcms Liver 
UnknownCardioprotective Regimen of Adaptation to Chronic Hypoxia Diversely Alters Myocardial Gene Expression in SHR and SHR-mtBN Conplastic Rat Strains.
Not available
S-EPMC6350269 | biostudies-literature
TranscriptomicsmicroRNA profiling of follicular lymphoma cells
The hallmark of follicular lymphoma (FL) is the t(14;18) chromosomal translocation. However, constitutive expression of anti-apoptotic Bcl-2 alone is insufficient for lymphomagenesis and subsequent molecular hits are required. We explored the role of microRNA (miRNA or miR) in the biology of FL by...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-28090 | biostudies-arrayexpress
ProteomicsIKACH IS CONSTITUTIVELY ACTIVE VIA PKC EPSILON IN AGING MEDIATED ATRIAL FIBRILLATION
Atrial fibrillation (AF), the most common abnormal heart rhythm, is a major cause for stroke. Aging is the greatest risk factor for AF, however, specific ionic pathways that can elucidate how aging leads to AF remain elusive. We used young and old wild type (WT) and PKC epsilon (PKCepsilon) knockout...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-07 | MSV000090489 | MassIVE
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