15d-pgj2 - OmicsDI

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Resolvin D3 (2)
15d-PGJ2 (2)
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AA (2)
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Tags

xref:PubMed:24980431 (1)
xref:PubMed:37019080 (1)

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Transcriptome profile of murine bone marrow-derived macrophages treated with 15d-PGJ2 or 15d-PGJ2-PC

Purpose: The goal of this study is to investigate the alteration of gene expression pattern induced by 15d-PGJ2 or 15d-PGJ2-PC in BMDMs. Method: BMDMs obtained from C57BL/6 mice were treated with 15d-PGJ2, 15d-PGJ2-PC or media control for 6h. Then RNA sequence was generated by using the Illumina sys...

ORGANISM(S): Mus musculus

2016-08-24 | E-GEOD-85931 | biostudies-arrayexpress

Electrophilic lipid mediator 15-deoxy-M-NM-^T12,14-prostaglandin J2 modifies glucocorticoid signaling via receptor SUMOylation

Cortisol, the central stress hormone in humans, activates the glucocorticoid receptor (GR). Anti-inflammatory effects are the most important pharmaceutical effects mediated by the GR. Inasmuch as electrophilic cyclopentenone prostaglandin 15-deoxy-M-NM-^T12,14-prostaglandin J2 (15d-PGJ2) has potent ...

ORGANISM(S): Homo sapiens

2014-06-30 | E-GEOD-54087 | biostudies-arrayexpress

Identification of 15d-PGJ2 target proteins

15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) is an endogenous anti-inflammatory lipid derived from PGD2. One potential mechanism for its activity is the covalent modification of cellular proteins, via a reactive alpha,beta-unsaturated carbonyl group in its cyclopentenone ring, which in turn alter...

ORGANISM(S): Homo sapiens (Human)

2015-04-26 | PXD000006 | Pride