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MetabolomicsGlutamine-restricted diets restore sensitivity to KRASG12D inhibitor through the reversal of ANXA1-mediated metabolic reprogramming
This study investigates the mechanisms underlying KRASG12D inhibitor resistance and evaluates strategies to enhance treatment sensitivity. Our findings indicate that a glutamine-restricted diet not only reverses KRASG12D inhibitor resistance in PDAC but also achieves durable remission with long-term...
2026-06-27 | MTBLS14825 | MetaboLights
MetabolomicsClostridium butyricum MIYAIRI 588-induced protectin D1 has an anti-inflammatory effect on antibiotic-induced intestinal disorder
Metabolites are thought as the end products in cellular regulatory processes and their levels show the strongest relationships with the phenotype. Previously, we showed that the administration of Clostridium butyricum MIYAIRI 588 (CBM 588) upregulated protectin D1, an anti-inflammatory lipid metabol...
2020-10-14 | MTBLS2087 | MetaboLights
MetabolomicsFoHsf1 reprograms central metabolism via caffeine and vitamin D2 to modulate development and virulence of Fusarium oxysporum on Polygonatum kingianum
Root rot has severely affected the yield and quality of Polygonatum kingianum, and Fusarium oxysporum has been identified as the primary causal agent. To explore the virulence mechanisms of this pathogen, we performed a functional characterization of FoHsf1, a gene encoding a heat shock transcriptio...
2026-04-11 | MTBLS14221 | MetaboLights
ProteomicsAnalysis of proteins in supernatant and precipitate fractions of human bronchial smooth muscle cells by 1D SDS-PAGE and quantitative LC-MS/MS
Supernatant and precipitate protein fractions of human bronchial smooth muscle cells (HBSMC) after sonication and centrifugation were analyzed using 1D SDS-PAGE. The gel lanes were cube-cut into thirty-three 1.1 mm x 1.1 mm x 1 mm (gel thickness) squares and each gel piece was subjected to in-gel d...
ORGANISM(S): Homo sapiens (Human) 
2019-01-03 | PXD010036 | Pride
Precipitation fraction 1d sds-page Supernatant fraction Bronchial smooth muscle cells Quantitative lc-ms/ms 
UnknownMolecular weight assessment of proteins in total proteome profiles using 1D-PAGE and LC/MS/MS.
Not available
S-EPMC1182394 | biostudies-literature
UnknownMore Is Not Always Better: Evaluation of 1D and 2D-LC-MS/MS Methods for Metaproteomics.
Not available
S-EPMC6383543 | biostudies-literature
OtherIs label-free LC-MS/MS ready for biomarker discovery?
Data from ProteomeXchange, PXD ID: PXD002037. Experiment: 01, file: folder summary. Published as part of Proteomics Clin Appl. 2015 Feb 5 .
ORGANISM(S): Streptococcus_pyogenes_m1_gas, Streptococcus_pyogenes_manfredo 
GPM11210037526 | GPMDB
Resource Reanalysis 
OtherA double-barrel LC-MS/MS system to quantify 96 interactomes per day.
Data from ProteomeXchange, PXD ID: PXD001695. File: 20140827_EXQ00_FaHo_SA_SWI3_03.mzml. Published as part of Mol Cell Proteomics. 2015 Apr 17 . From the Abstract: {{i}} ... Here we develop a high-throughput workflow capable of dealing with large numbers of low or medium complexity samples and spec...
ORGANISM(S): Yeast 
GPM11210038526 | GPMDB
Resource Reanalysis 
UnknownA Comprehensive 2D-LC/MS/MS Profile of the Normal Human Urinary Metabolome.
Not available
S-EPMC9497905 | biostudies-literature
UnknownOnline 2D-LC-MS/MS Platform for Analysis of Glycated Proteome.
Not available
S-EPMC5951789 | biostudies-literature
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