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MetabolomicsMeasurement of 2-hydroxyglutarate for reproducibility project
Not available
ORGANISM(S): Homo sapiens 
ST000904 | MetabolomicsWorkbench
Metabolomics2 hydroxyglutarate prodution in neurospheres from IDH1 mouse glioma model #2
Not available
ORGANISM(S): Mus musculus 
ST000820 | MetabolomicsWorkbench
MetabolomicsReplication study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
Not available
ORGANISM(S): Homo sapiens 
ST000548 | MetabolomicsWorkbench
Transcriptomics2-hydroxyglutarate modulates histone methylation using both RNA/ChIP-seq
2-hydroxyglutarate (2-HG) is an oncometabolite accumulating in certain cancers and some neurometabolic diseases. In cancers 2-HG accumulation is induced by a gain-of-function mutation in isocitrate dehydrogenase (IDH) genes, leading to conversion of alpha-ketoglutarate (a-KG) into 2-HG
ORGANISM(S): Saccharomyces cerevisiae S288C 
2023-04-15 | E-MTAB-11328 | biostudies-arrayexpress
Proteomics2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
Mitochondria play a crucial role in regulating cellular homeostasis in response to intrinsic and extrinsic cues by changing cellular metabolism to meet these challenges. However, the molecular underpinnings of this regulation and the complete spectrum of these physiological outcomes remain largely u...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD064288 | Pride
Nuclear softening Brown adipose tissue Mitochondria 2-hydroxyglutarate 
TranscriptomicsSuppression of antitumor immunity by the oncometabolite 2-hydroxyglutarate
Isocitrate dehydrogenase (IDH) mutations, a hallmark of gliomagenesis, result in the production of the oncometabolite R-2-hydroxyglutarate (R-2-HG) which is thought to promote tumorigenesis via DNA methylation. Here we identify an additional immunosuppressive activity of R-2-HG: Tumor cell-derived R...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-84849 | biostudies-arrayexpress
Genomics2-hydroxyglutarate modulates histone methylation using both RNA/ChIP-seq
2-hydroxyglutarate modulates histone methylation using both RNA/ChIP-seq
PRJEB50081 | ENA
GenomicsR-2-hydroxyglutarate-mediated inhibition of KDM4A disrupts telomere integrity
R-2-hydroxyglutarate-mediated inhibition of KDM4A disrupts telomere integrity
PRJNA1196302 | ENA
GenomicsMitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [CUT&Run]
Mitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [CUT&Run]
PRJNA1363940 | ENA
GenomicsMitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [mRRBS]
Mitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [mRRBS]
PRJNA1445071 | ENA
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