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MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
MetabolomicsFoHsf1 reprograms central metabolism via caffeine and vitamin D2 to modulate development and virulence of Fusarium oxysporum on Polygonatum kingianum
Root rot has severely affected the yield and quality of Polygonatum kingianum, and Fusarium oxysporum has been identified as the primary causal agent. To explore the virulence mechanisms of this pathogen, we performed a functional characterization of FoHsf1, a gene encoding a heat shock transcriptio...
2026-04-11 | MTBLS14221 | MetaboLights
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
TranscriptomicsExamination of protein expression patterns of closely related Salmonella serovars using 2D GE and MS/MS
The objective of the present investigation was to consider the level of variation in the protein expression patterns of closely related Salmonella serovars, in order to search for protein factors with levels of expression or posttranslational modifications characteristic for each serovar. For the co...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Enteritidis 
2008-02-26 | E-GEOD-8931 | biostudies-arrayexpress
ProteomicsExtending proteome coverage through an on-line 2D SCX-RP ultra-high pressure system
Ultra high pressure liquid chromatography (UHPLC) systems combined with state of the art mass spectrometers have pushed the limit of deep proteome sequencing to new heights making it possible to identify thousands of proteins in a single LC/MS experiment within a few hours. However, the relationship...
ORGANISM(S): Homo sapiens (Human) 
2014-09-30 | PXD000705 | Pride
2d lc-ms/ms Proteomics 
ProteomicsForrester, M.T. et al., Nat. Biotech, 2009.
Not available
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Escherichia coli 
2009-12-01 | PRD000112 | Pride
ProteomicsMURDOCK - Duke Hepatitis C - Predicting Treatment response to Hepatitis C, PEG-IFN/Ribavirin
Predicting Treatment response to Hepatitis C, PEG-IFN/Ribavirin
ORGANISM(S): Hepatitis C virus genotype 1 Hepatitis C virus subtype 1a 
2010-01-04 | PRD000181 | Pride
ProteomicsMore is not always better: Evaluation of 1D- and 2D-LC-MS2 methods for metaproteomics
Metaproteomics is a powerful tool to characterize the structure of microbial communities and the physiology, metabolism and interactions of the species in these communities. Metaproteomics seeks to identify and quantify proteins from microbial communities on a large scale using gel electrophoresis o...
ORGANISM(S): Eukaryota (eucaryotes) Bacteria Archaea Viruses 
2019-02-12 | PXD008017 | Pride
Microbial community  microbiota  microbiome  mock community  method evaluation  microbial ecology  q exactive  liquid chromatography  gelc 
ProteomicsAgriope Proteins from 2D-Gel and LC-ESI
Agriope Proteins from 2D-Gel and LC-ESI-MS approach
ORGANISM(S): Bos taurus (Bovine) 
2021-09-09 | PXD018693 | Pride
Maldi-tof ms  lc-esi-ms 2-d gelelectrophoresis 
ProteomicsIdentification of novel serum biomarkers for malignant mesothelioma using iTRAQ combined with 2D-LC-MS/MS
In this project, differential serum proteins (DEPs) were first screened in MM patients and healthy controls using iTRAQ labeling coupled with 2D LC-MS/MS method. As a result, 475 proteins were identified, of which, 327 proteins contain at least two unique peptides, and 145 DEPs were found between M...
ORGANISM(S): Homo Sapiens 
2019-10-30 | PXD016073 |
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