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ProteomicsA comparison of human skeletal muscle cell maturation in 2D versus 3D culture: A quantitative proteomic study C4PR_LIV
Background Three-dimensional (3D) bioengineered models of human skeletal muscle are a promising approach for studying muscle development, function and disease in vitro. These models more closely resemble the complexity of native muscle tissue than two-dimensional (2D) monolayer culture and allow for...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD061227 | Pride
Bioengineering In vitro models Skeletal muscle Maturation Proteomics 3d culture Hydrogel 
TranscriptomicsDevelopment of a 3D Bone Marrow Adipose Tissue Model
Herein we compare mouse (C57B6/J background, 16 week old) adherent bone marrow stromal cell gene expression after 4 weeks of adipogenic differentiation in 3D versus 2D culture. Adipogenic differentiation was compared on a 3D silk scaffold versus a 2D (tissue culture plastic) surface using an microar...
ORGANISM(S): Mus musculus 
2018-12-19 | GSE108374 | GEO
ProteomicsHigh temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development
Primary human hepatocytes are widely used to evaluate liver toxicity of drugs, but they are scarce and demanding to culture. Stem cell-derived hepatocytes are increasingly discussed as alternatives. To obtain a better appreciation of the molecular processes during the differentiation of induced plur...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD027439 | Pride
Hepatocyte differentiation Quantitative mass spectrometry Phosphoproteomics 2d versus 3d differentiation Stem cell-derived organoids 
GenomicsDeciphering the Divergent Transcriptomic Landscapes of Cervical Cancer Cells Grown in 3D and 2D Cell Culture Systems
Deciphering the Divergent Transcriptomic Landscapes of Cervical Cancer Cells Grown in 3D and 2D Cell Culture Systems
PRJNA1127667 | ENA
TranscriptomicsDeciphering the Divergent Transcriptomic Landscapes of Cervical Cancer Cells Grown in 3D and 2D Cell Culture Systems
Cervical cancer remains a significant health challenge for women worldwide, with a disproportionate impact on developing regions like sub-Saharan Africa. Taking advantage of recent advancements in developing suitable preclinical models to study cell proliferation, differentiation, and gene expressio...
ORGANISM(S): Homo sapiens 
2024-09-13 | GSE270674 | GEO
UnknownLabel-free and real-time monitoring of human mesenchymal stem cell differentiation in 2D and 3D cell culture systems using impedance cell sensors.
Not available
S-EPMC9085567 | biostudies-literature
GenomicsDevelopment of a 3D Bone Marrow Adipose Tissue Model
Development of a 3D Bone Marrow Adipose Tissue Model
PRJNA423294 | ENA
UnknownHeterogeneous Differentiation of Human Mesenchymal Stem Cells in 3D Extracellular Matrix Composites.
Not available
S-EPMC4744874 | biostudies-literature
UnknownDeciphering the divergent transcriptomic landscapes of cervical cancer cells grown in 3D and 2D cell culture systems.
Not available
S-EPMC11347336 | biostudies-literature
Unknown3D spheroids versus 2D-cultured human adipose stem cells to generate smooth muscle cells in an internal anal sphincter-targeting cryoinjured mouse model.
Not available
S-EPMC11470548 | biostudies-literature
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