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TranscriptomicsProgressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development
The 3' untranslated regions (3' UTRs) of mRNAs contain cis-acting elements for posttranscriptional regulation of gene expression. Here, we report that mouse genes tend to express mRNAs with longer 3' UTRs as embryonic development progresses. This global regulation is controlled by alternative polyad...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23871 | biostudies-arrayexpress
TranscriptomicsGenome?wide analysis of pre?mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length: A-seq
Through alternative polyadenylation, human mRNAs acquire longer or shorter 3' untranslated regions, the latter typically associated with higher transcript stability and increased protein production. To understand the dynamics of polyadenylation site usage, we mapped transcriptome?wide both binding s...
ORGANISM(S): Homo sapiens 
2012-05-15 | E-GEOD-37037 | biostudies-arrayexpress
ProteomicsA new cost-effective ribosome profiling technique complements the functional genome annotation and reveals a key role of genic 3’ untranslated region in plant translatomic variation
A new cost-effective ribosome profiling technique complements the functional genome annotation and reveals a key role of genic 3’ untranslated region in plant translatomic variation
ORGANISM(S): Zea mays (Maize) 
2021-05-30 | PXD019635 | Pride
Eqtl Maize 3'ribo-seq Protein ms 
TranscriptomicsGenome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length: CLIP
Through alternative polyadenylation, human mRNAs acquire longer or shorter 3' untranslated regions, the latter typically associated with higher transcript stability and increased protein production. To understand the dynamics of polyadenylation site usage, we mapped transcriptome‐wide both binding s...
ORGANISM(S): Homo sapiens 
2012-05-15 | E-GEOD-37398 | biostudies-arrayexpress
ProteomicsIdentification of human mRNA processing complexes bound to histone H2A.2 3’ untranslated region
Processing of 3’ untranslated region (3’-UTR) of precursor messenger RNAs (pre-mRNA) is a fundamental step in mRNA maturation, where the mRNA transcript is cleaved at a specific site, located downstream the open reading frame of the encoded gene. The position of the cleavage site is determined by ci...
ORGANISM(S): Homo sapiens (Human) 
2022-12-09 | PXD027636 | Pride
3’-utr Mrnas Nanolc-ms/ms 3’ pre-mrna processing complexes 
TranscriptomicsThe systematic shortening of 3’ UTRs has limited influence on the relative change in protein abundance in proliferating cells
Alternative polyadenylation is an important cellular mechanism that enables generation of mRNA isoforms that differ in their 3' untranslated regions (3' UTRs) and consequently in their susceptibility to miRNA and RNA binding protein mediated regulation. A dramatic change in polyadenylation site usa...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-54950 | biostudies-arrayexpress
TranscriptomicsExon array analysis of resting and activated primary murine CD4+ T-cells
The stability, localization and translation of mammalian mRNAs are largely determined by sequences in the 3' untranslated region (UTR). Here, we describe a conserved program of increased upstream polyadenylation site usage following activation of primary murine CD4+ T lymphocytes. This program, re...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10666 | biostudies-arrayexpress
ProteomicsIdentification of mRNA processing complexes bound to histone H2A.2 3’ untranslated region
Processing of 3’ untranslated region (3’-UTR) of precursor messenger RNAs (pre-mRNA) is a fundamental step in mRNA maturation, where the mRNA transcript is cleaved at a specific site, located downstream the open reading frame of the encoded gene. The position of the cleavage site is determined by ci...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-12-09 | PXD034984 | Pride
Pre-mrna processing Processing factors Nanolc-ms/ms Mrna maturation 
TranscriptomicsWhole genome analysis of cells permissive for late gene expression of HPV-16
Aim was to identify cellular factors that regulate HPV-16 late gene expression at the level of RNA processing Cervical cancer cells permissive for HPV16 late gene expression were identified and characterized. These cells either contained a novel spliced variant of the L1 mRNAs that bypassed the supp...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-65166 | biostudies-arrayexpress
GenomicsThe 3’ Untranslated Region (3’UTR) Coding Sequence of PHO84, Rather Than the Antisense RNA, Promotes Gene Repression
The 3’ Untranslated Region (3’UTR) Coding Sequence of PHO84, Rather Than the Antisense RNA, Promotes Gene Repression
PRJNA944239 | ENA
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