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MetabolomicsSystemic Inflammation Induces Cholestasis via Upregulating a Short Variant of FTO to Remove the m6A Methylation in the 3’-UTR of Cyp7b1 mRNAs in liver
The cholestasis frequently occurs in patients with inflammatory processes. However, the mechanisms of inflammation in inducing cholestasis are still unclear. Here, by using lipopolysaccharide (LPS)-induced cholestasis mouse models, we found that most genes encoding enzymes responsible for bile acid ...
2025-11-07 | MTBLS10713 | MetaboLights
ProteomicsTranslating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype specific
As a well-known phenomenon, total mRNAs poorly correlate to proteins in their abundances as reported. Recent findings calculated with bivariate models suggested even poorer such correlation, whereas focusing on the translating mRNAs (ribosome nascent-chain complex-bound mRNAs, RNC-mRNAs) subset. In ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-25 | PXD005299 | Pride
Translation ratios，translating mrnas 
ProteomicsIdentification of proteins interacting with translating RPAC reporter mRNAs (FGH17)
To discover new regulators of Regulatory Particle Assembly Chaperone (RPAC) translation, we identified RNA-binding proteins (RBPs) with increased recruitment to translating WT FGH17 mRNAs compared to non-translatable FGH17-40ntΔ mRNAs in vivo. To this end, we first treated yeast cells with rapamycin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-05-04 | PXD027655 | Pride
Proteasome assembly chaperone translation 
TranscriptomicsGlobal analysis of differential polyadenylation of mRNAs during mitotic cell cycle: S phase versus G2/M phase.
We compared the poly(A) tail length status of mRNAs of HeLa cells between two phases of the mitotic cell cycle: S and G2/M phases. Hundreds of mRNAs were found to be regulated by changes in their poly(A) tail length during mitotic cell cycle in a phase specific manner. Many of these differentially p...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-15399 | biostudies-arrayexpress
TranscriptomicsPoly(A) tail length profiling of mRNAs from fission yeast
To obtain global data on polyadenylation of mRNAs, we fractionated the mRNAs according to their poly(A) tail length using a poly-U sepharose column followed by differential elution at five temperatures. Five mRNA fractions with distinct ranges of poly(A) tail length were then hybridized to microarr...
ORGANISM(S): Schizosaccharomyces pombe 
2007-05-16 | E-TABM-217 | biostudies-arrayexpress
TranscriptomicsTranslation State Array Assay for C elegans IFE-1-dependent mRNAs
Relative polysomal loading changes for wild type (N2) versus ife-1(bn127) C. elegans strains Strain ife-1(bn127) is null for the gene encoding one of five eIF4E isoforms in the worm, IFE-1. Only this isoform associates with P granules. Resolution of translating and non-translating mRNAs from WT and...
ORGANISM(S): Caenorhabditis elegans 
2016-01-07 | E-GEOD-74459 | biostudies-arrayexpress
TranscriptomicsmRNAs translated at eIF4F
Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray. Although most eukaryotic mRNAs need a functional cap binding complex eIF4F for efficient 5' end-dependent scanning to initiate translation, picornaviral, hepatitis C vi...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-62 | biostudies-arrayexpress
GenomicsQuantitative comparison between cellular mRNAs and exosomal mRNAs in human iPSC-derived motor neurons
Quantitative comparison between cellular mRNAs and exosomal mRNAs in human iPSC-derived motor neurons
PRJNA557223 | ENA
Genomics8-week WT or Ftsj1 KO mouse brain total mRNAs and ribosome-contained mRNAs
8-week WT or Ftsj1 KO mouse brain total mRNAs and ribosome-contained mRNAs
PRJNA643980 | ENA
TranscriptomicsIRES containing mRNAs and mitotic cell cycle
A cell synchronization protocol was established in which global and individual mRNA translational efficiencies could be examined. While global translational efficiency was reduced in mitotic cells, approximately 3% of mRNAs remained predominantly associated with large polysomes during mitosis, as de...
ORGANISM(S): Homo sapiens 
2005-12-30 | E-GEOD-3957 | biostudies-arrayexpress
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