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TranscriptomicsThe systematic shortening of 3’ UTRs has limited influence on the relative change in protein abundance in proliferating cells
Alternative polyadenylation is an important cellular mechanism that enables generation of mRNA isoforms that differ in their 3' untranslated regions (3' UTRs) and consequently in their susceptibility to miRNA and RNA binding protein mediated regulation. A dramatic change in polyadenylation site usa...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-54950 | biostudies-arrayexpress
GenomicsDifferentiation of syncytialized trophoblasts elicits widespread 3’UTR shortening that accompanies increased cellular function in protein secretion
Differentiation of syncytialized trophoblasts elicits widespread 3’UTR shortening that accompanies increased cellular function in protein secretion
PRJNA577069 | ENA
ProteomicsChanges in proteome upon mTOR activation
mTOR activation has been known to affect protein synthesis. To identify molecular signatures in transcriptome that could enhance protein synthesis, RNA-seq and quantitative proteomics studies were conducted using WT and TSC1 null MEFs. In this study, we found that the activation of mTOR leads to gen...
ORGANISM(S): Mus musculus (Mouse) 
2015-06-16 | PXD002006 | Pride
3'utr shortening Ubiquitin-mediated proteolysis Alternative polyadenylation Mtor 
UnknownEstrogen-induced upregulation and 3'-UTR shortening of CDC6.
Not available
S-EPMC3510512 | biostudies-literature
TranscriptomicsDifferentiation of syncytialized trophoblasts elicits widespread 3’UTR shortening that accompanies increased cellular function in protein secretion
Most eukaryotic genes express alternative polyadenylation (APA) isoforms with different 3’UTR sizes. The APA profile varies across tissue types and under different growth and differentiation conditions. Here we report that, unlike many other cell differentiation lineages, differentiation of syncytio...
ORGANISM(S): Mus musculus Homo sapiens 
2020-05-15 | GSE138759 | GEO
Unknown3' UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk.
Not available
S-EPMC6689271 | biostudies-literature
TranscriptomicsCPEB inducible knock-down in a H.D. Myz cell line
Messenger RNA stability, localization, and translation are largely determined by sequences in their 3M-bM-^@M-2 untranslated regions (3M-bM-^@M-^YUTRs), which recruit regulatory proteins and RNAs. More than half of the mammalian genes generate multiple mRNA isoforms differing in their 3M-bM-^@M-2UTR...
ORGANISM(S): Homo sapiens 
2013-02-25 | E-GEOD-32440 | biostudies-arrayexpress
Unknown3'UTR shortening alleviates miRNA repression of mRNAs critical for muscle stem cell differentiation.
Not available
S-EPMC12864877 | biostudies-literature
UnknownIMP1 3' UTR shortening enhances metastatic burden in colorectal cancer.
Not available
S-EPMC6556707 | biostudies-literature
Unknown3'UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells.
Not available
S-EPMC4764332 | biostudies-literature
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