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TranscriptomicsGlobal expression of mouse hepatocytes cultured as monolayers or as three-dimensional aggregates
Three-dimensional (3D) culture of hepatocytes leads to improved and prolonged synthetic and metabolic functions, but the underlying molecular mechanisms were unknown. In order to investigate the molecular mechanisms underlying 3D cell-cell interactions in maintaining hepatocyte differentiated funct...
ORGANISM(S): Mus musculus 
2013-12-23 | E-GEOD-53054 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of primary human bone marrow mesenchymal stromal cells (MSCs) cultured as 2D monolayers and 3D cellular aggregates (spheroids)
Human bone marrow mesenchymal stromal cells (MSCs) are conventionally cultured as adherent monolayers on tissue culture plastic. MSCs can also be cultured as 3D cell aggregates (spheroids). Optimised 3D conditions (60,000 MSCs cultured as a spheroid for 5 days) inhibited MSC proliferation and induce...
ORGANISM(S): Homo sapiens 
2015-09-30 | E-MTAB-3795 | biostudies-arrayexpress
ProteomicsEngineering Extracellular Vesicles by Three-dimensional Dynamic Culture of Human Mesenchymal Stem Cells
Extracellular vesicles (EVs) contain proteins, enzymes and metabolites that contribute to the therapeutic potential of human mesenchymal stem cells (hMSCs). However, scale-up production of hMSC EVs has become a major challenge. In current study, hMSCs were grown as 3D aggregates under wave motion to...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD028975 | Pride
Biogenesis Human mesenchymal stem cells Extracellular vesicles Immunomodulation 3d aggregates Rejuvenation 
TranscriptomicsMouse iPS cells-derived 3D-retinas: Vehicle control- vs. 4-hydroxytamoxifen (4-OHT)-treated 3D-retinas
Transcriptional profiling of 3D-retinas differentiated from mouse iPS cells comparing vehicle control- with 4-OHT-treated. 4-OHT is an inverse agonist of estrogen-related receptor beta (ERRβ), a rod-enriched transcription factor responsible for maintenance of rod photoreceptor cells and the treatme...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-83985 | biostudies-arrayexpress
MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
TranscriptomicsMouse iPS cells-derived 3D-retinas: Vehicle control- vs. 4-hydroxytamoxifen (4-OHT)-treated 3D-retinas w/o supplements
Transcriptional profiling of 3D-retinas differentiated from mouse iPS cells comparing vehicle control with 4-OHT-treated w/o supplements. 4-OHT is an inverse agonist of estrogen-related receptor beta (ERRβ), a rod-enriched transcription factor responsible for maintenance of rod photoreceptor cells...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-83984 | biostudies-arrayexpress
Genomics3D + LY vs. 3D culture of HUASMC
3D + LY vs. 3D culture of HUASMC
PRJNA552085 | ENA
TranscriptomicsCombined analysis of single cell RNA-Seq and ATAC-Seq data reveals regulatory toggles operating in native and iPS-derived retina
To improve the comparison of the developmental trajectories of native retina (NaR) and iPSC-derived 3D retinal aggregates(3D-RA) , we performed scRNA-Seq of murine NaR and 3D-RA at four matched stages of development: embryonic day (E)13 vs differentiation day (DD)13, postnatal day (P)0 vs DD21, P5 v...
ORGANISM(S): Mus musculus 
2021-06-30 | E-MTAB-9395 | biostudies-arrayexpress
UnknownReal-time monitoring of quorum sensing in 3D-printed bacterial aggregates using scanning electrochemical microscopy.
Not available
S-EPMC4280622 | biostudies-literature
TranscriptomicsATAC-Seq using native and iPSC-derived murine retina at three developmental stages.
To identify epigenetic programs underlying differentiation of mouse retina, we performed ATAC-Seq on bulk native retina (NaR) and iPSC-derived 3D retinal aggregates (3D-RA) at three matched stages of development: embryonic day (E)13 vs differentiation day (DD)13, postnatal day (P)0 vs DD21, and P5 v...
ORGANISM(S): Mus musculus 
2021-06-30 | E-MTAB-9440 | biostudies-arrayexpress
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