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TranscriptomicsSnapshots of pre-rRNA structural flexibility reveal eukaryotic 40S assembly dynamics at nucleotide resolution
Ribosome assembly in eukaryotes involves the activity of hundreds of assembly factors that direct the hierarchical assembly of ribosomal proteins and numerous ribosomal RNA folding steps. However, detailed insights into the function of assembly factors and ribosomal RNA folding events are lacking. T...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-14 | E-GEOD-52878 | biostudies-arrayexpress
ProteomicsSmall and large ribosomal subunit deficiencies lead to distinct gene expression signatures that reflect cellular growth rate
Levels of the ribosome, the conserved molecular machine that mediates translation, are tightly linked to cellular growth rate. In humans, ribosomopathies are diseases associated with cell-type-specific pathologies and reduced ribosomal protein (RP) levels. Because gene expression defects resulting f...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2018-10-12 | MSV000083033 | MassIVE
GenomicseIF2D promotes 40S ribosomal subunit recycling during intrinsic ribosome destabilization
eIF2D promotes 40S ribosomal subunit recycling during intrinsic ribosome destabilization
PRJNA1219200 | ENA
ProteomicsProteomics analysis of human pre-40S ribosomal particles
Proteomics analysis of late human pre-40S particles purified using a catalytically-inactive RIO1 as bait. Analysis of RIO1(kd)-StHA pre-40S particles composition upon RPS26 depletion with siRNA.
ORGANISM(S): Homo sapiens (Human) 
2021-05-12 | PXD019270 | Pride
Ribosomal particles 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. S6B]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060299 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 2F]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060349 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 7D, S7G]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060301 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. S6C-D]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060294 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 6B-D]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060208 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 4D, S4D]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060334 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
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