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ProteomicsRole of 4EBP1/2 in the response to glucose deprivation
We investigated the function of the mTORC1 substrates and mRNA translation regulators 4EBP1/2 in the response to glucose deprivation. We uncovered that targeting 4EBP1/2 expression had a direct impact on the survival rates of cells challenged with glucose deprivation. To further define the mechanism...
ORGANISM(S): Homo sapiens (Human) 
2024-03-28 | PXD040931 | Pride
Glucose starvation Stress response 4ebp1/2 Mrna translation Mtorc1 
GenomicsDistinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAs [4EBP1/2]
Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAs [4EBP1/2]
PRJNA975192 | ENA
TranscriptomicsDistinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAs [4EBP1/2]
To investigate the changes in gene expression upon loss of 4EBP1/2, we performed RNA-seq and differential gene expression analysis on WT and derived 4EBP1/2 KD cell lines. The canonical and 5′TOP mRNA cell lines used for single-molecule imaging were treated as biological replicates for the different...
ORGANISM(S): Homo sapiens 
2024-01-15 | GSE233182 | GEO
GenomicsTargeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translational regulation of mRNAs encoding ribosomal proteins
Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translational regulation of mRNAs encoding ribosomal proteins
PRJNA485510 | ENA
UnknownDephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell Quiescence.
Not available
S-EPMC9948964 | biostudies-literature
TranscriptomicsTargeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translational regulation of mRNAs encoding ribosomal proteins
The PI3K-Akt-mTOR signaling pathway is a master regulator of RNA translation. Pharmacological inhibition of this pathway preferentially and coordinately suppresses, in a 4EBP1/2-dependent manner, translation of mRNAs encoding ribosomal proteins. However, it remains unclear whether mTOR-4EBP1/2 is th...
ORGANISM(S): Homo sapiens 
2018-09-21 | GSE118422 | GEO
UnknownDistinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5'TOP mRNAs.
Not available
S-EPMC10871529 | biostudies-literature
UnknownTargeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins.
Not available
S-EPMC6176620 | biostudies-literature
UnknownVirus-induced translational arrest through 4EBP1/2-dependent decay of 5'-TOP mRNAs restricts viral infection.
Not available
S-EPMC4460451 | biostudies-literature
GenomicsDistinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAs
Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAs
PRJNA975195 | ENA
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