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MetabolomicsCapsaicin ameliorates glycemic levels via gut microbiota-derived 5-aminolevulinic acid in mice

Background: Capsaicin, a natural alkaloid in chili peppers, regulates glycemic levels, however, its mechanisms and therapeutic potential remain unclear. This study aimed to elucidate the role of gut microbiota and their metabolites in mediating capsaicin’s glycemic regulatory effects. We conducte...

2025-06-13 | MTBLS12575 | MetaboLights
MetabolomicsGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
2021-12-08 | MTBLS3174 | MetaboLights
MetabolomicsATP-binding Cassette Sub-family C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs
The ubiquitous efflux transporter ATP-binding cassette sub-family C member 5 (ABCC5) is present at high levels in the blood-brain barrier, neurons and glia, but its function is not known. Untargeted metabolomic screens revealed that Abcc5-/- mice accumulate endogenous glutamate conjugates in several...
2015-11-02 | MTBLS197 | MetaboLights
MetabolomicsRapid biotransformation of STW 5 constituents by human gut microbiome from IBS- and non-IBS donors

STW 5, a blend of 9 medicinal plant extracts, exhibits promising efficacy in treating functional gastrointestinal disorders, notably irritable bowel syndrome (IBS). Nonetheless, its effects on the gastrointestinal microbiome and the role of microbiota on the conversion of its constituents are sti...

2024-05-07 | MTBLS2398 | MetaboLights
MetabolomicsPrimary T Cell Baseline (Donor 5) - II
Not available
ORGANISM(S): Homo sapiens 
ST000144 | MetabolomicsWorkbench
MetabolomicsMetabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice
It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male,...
2018-06-20 | MTBLS667 | MetaboLights
MetabolomicsACSL5 Whole Body Bile Acids
Not available
ORGANISM(S): Mus musculus 
ST000195 | MetabolomicsWorkbench
MetabolomicsMetagenomics and Metabolomics Integrated to Explore the Protective Mechanisms of Mongolian Medicine Zadi-5 in Myocardial Ischemic Model Rats

Myocardial ischemia(MI) is a pathological state of abnormal energy metabolism due to insufficient blood and oxygen supply to the coronary arteries. The 'gut-heart axis' theory plays an important role in myocardial ischemia occurrence, mechanism, prevention, and cure. Traditional Mongolian medicin...

2026-01-27 | MTBLS13780 | MetaboLights
MetabolomicsA Calorie-restricted Dietary Intervention Alleviates Obesity-induced MASLD via the Microbiota-5-hydroxyindoleacetic acid–Pregnane X Receptor Axis

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents the most common chronic liver disease worldwide. Caloric restriction (CR) is a major dietary intervention known to reshape the gut microbiota; however, the implications of these microbial changes for MASLD pathophysiology...

2026-01-14 | MTBLS13675 | MetaboLights
MetabolomicsAlleviation of Loperamide-Induced Constipation by Lactiplantibacillus plantarum SYS1: Role of Properistaltic Metabolites and Promotion of Enteric Nerve Development via 5-HT4R Activation

Background: Constipation is a common gastrointestinal disorder. Lactobacillus plantarum has been reported to have the effect of relieving constipation, but its underlying mechanism remains unclear.

Results: Lactiplantibacillus plantarum SYS1 was identified through in ...

2025-08-06 | MTBLS12821 | MetaboLights
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