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Metabolomics1H NMR Metabolomics Reveals Association of High Expression of Inositol 1, 4, 5 Trisphosphate Receptor and Metabolites in Breast Cancer Patients
1H NMR is used to detect alterations in metabolites and their linkage to metabolic processes in a number of pathological conditions including breast cancer. Inositol 1, 4, 5 trisphosphate (IP3R) receptor is an intracellular calcium channel known to regulate metabolism and cellular bioenergetics. Its...
2017-07-18 | MTBLS326 | MetaboLights
ProteomicsCaspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology
Contactin-associated protein-like 2 (Caspr2) is a neurexin-like protein that has been associated with numerous neurological conditions. However, the mechanisms underlying Caspr2 function in the central nervous system remain incompletely understood. Here, we report on a functional role for Caspr2 in ...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-13 | PXD018972 | Pride
5-trisphosphate receptor type 1  cerebellum  purkinje cell 4 Caspr2  itpr  inositol 1 
Unknown1H NMR Metabolomics Reveals Association of High Expression of Inositol 1, 4, 5 Trisphosphate Receptor and Metabolites in Breast Cancer Patients.
Not available
S-EPMC5225010 | biostudies-literature
TranscriptomicsChromatin immunoprecipitation of the MSL-1 and MSL-3 vs a mock IP in Drosophila and transcription profiling of X linked genes in WT male or female III instar larvae to provide X chromosome wide profiling of MSL-1 distribution and dosage compensation in Drosophila
Dosage compensation ensures that males and females, despite unequal number of X chromosomes, equalize for X linked gene expression. In Drosophila, it is achieved by a two-fold up-regulation of most of the genes present on the male X chromosome, and requires the association of the Dosage Compensation...
ORGANISM(S): Drosophila melanogaster 
2006-04-01 | E-MEXP-554 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis wild type and transgenic plants response to water stress
Transgenic Arabidopsis plants with constitutively low inositol (1,4,5) triphosphate exhibit an increased tolerance to water stress by an ABA-independent pathway; The phosphoinositide pathway and inositol (1,4,5) trisphopsphate (InsP3) are implicated in plant responses to stress. In order to manipula...
ORGANISM(S): Arabidopsis thaliana 
2008-10-25 | E-GEOD-10670 | biostudies-arrayexpress
TranscriptomicsSynergy between plasminogen activator inhibitor-1 and Snail in tumoral migration
Snail, a family of transcriptional repressors implicated in cell movement, has been correlated with tumour invasivity. The Plasminogen Activation system (PAs), including urokinase (uPA), its receptor (uPAR), and its inhibitor (PAI-1), also plays a key role in cancer invasion and metastasis, either t...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10395 | biostudies-arrayexpress
TranscriptomicsChromatin immunopreciptiation to identify thyroid hormone receptor beta-1 binding sites in mouse cerebellum
chip on chip to identify thyroid hormone receptor responsive gene
ORGANISM(S): Mus musculus 
2009-04-03 | E-MEXP-1801 | biostudies-arrayexpress
TranscriptomicsNF1 microdeletions characterization by custom high-resolution array CGH
To allow accute charaterization of NF1 locus constitutional microdeletion in 70 NF1 patients, a custom array CGH was developped. Goal was to obtain genomic rearrangements fine characterization in order to perform genotype-phenotype correlation in NF1 microdeleted patients. To serve as a reference g...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-19730 | biostudies-arrayexpress
TranscriptomicsPI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer
Activating mutations of PIK3CA are the most frequent genomic alterations in estrogen receptor (ER)-positive breast tumors and selective PI3Kα inhibitors are in clinical development. The activity of these agents, however, is not homogenous and only a fraction of patients bearing PIK3CA-mutant ER-posi...
ORGANISM(S): Homo sapiens 
2015-04-29 | E-GEOD-64033 | biostudies-arrayexpress
TranscriptomicsAge-Dependent Differences in Gene Expression in Response to Calvarial Injury
Children less than 2 years of age are capable of healing large calvarial defects, whereas adults have been found to lack this endogenous ability. In this study, we used microarray analysis to compare genomewide expression patterns during active regeneration after injury with calvaria in skeletally i...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-14424 | biostudies-arrayexpress
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