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ProteomicsCaspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology
Contactin-associated protein-like 2 (Caspr2) is a neurexin-like protein that has been associated with numerous neurological conditions. However, the mechanisms underlying Caspr2 function in the central nervous system remain incompletely understood. Here, we report on a functional role for Caspr2 in ...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-13 | PXD018972 | Pride
5-trisphosphate receptor type 1  cerebellum  purkinje cell 4 Caspr2  itpr  inositol 1 
TranscriptomicsCaptopril Restores Microglial Homeostasis and Reverses ASD-like Phenotype in a model of ASD induced by exposure in utero to anti-Caspr2 IgG.
We performed single-cell RNA sequencing (scRNA-seq) of hippocampal microglia to define transcriptional changes induced by prenatal exposure to maternal anti-Caspr2 antibodies and their modulation by treatment (Captopril). Male offspring were analyzed across four main groups: (1) Saline-treated Contr...
ORGANISM(S): Mus musculus 
2025-09-22 | GSE308428 | GEO
GenomicsCaptopril Restores Microglial Homeostasis and Reverses ASD-like Phenotype in a model of ASD induced by exposure in utero to anti-Caspr2 IgG.
Captopril Restores Microglial Homeostasis and Reverses ASD-like Phenotype in a model of ASD induced by exposure in utero to anti-Caspr2 IgG.
PRJNA1330399 | ENA
UnknownCaspr2 autoantibodies target multiple epitopes.
Not available
S-EPMC4496632 | biostudies-literature
UnknownObjective sleep profile in LGI1/CASPR2 autoimmunity.
Not available
S-EPMC8842336 | biostudies-literature
UnknownHeterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity.
Not available
S-EPMC12644748 | biostudies-literature
UnknownInvestigations of caspr2, an autoantigen of encephalitis and neuromyotonia.
Not available
S-EPMC3059252 | biostudies-literature
UnknownDistinct HLA associations of LGI1 and CASPR2-antibody diseases.
Not available
S-EPMC6118231 | biostudies-literature
UnknownCASPR2 Autoimmune Antibodies Induce Neuronal Hyperactivity in Human Brain Organoids.
Not available
S-EPMC12926859 | biostudies-literature
UnknownInhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis.
Not available
S-EPMC4496579 | biostudies-literature
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