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MetabolomicsUrolithin A (UroA) acts at CYP1A1/1B1 substrates leading to enhanced aryl hydrocarbon receptor (AHR) activity in vivo
Not available
ORGANISM(S): Mus musculus 
ST002481 | MetabolomicsWorkbench
TranscriptomicsRNA-seq of hepatocytes obtained through step-wise differentiation of hIPSCs from a patient with A1AT deficiency and its point mutation-corrected isogenic hIPSC line. Comparison to primary hepatocytes from a healthy donor and an A1AT-deficient patient.
A1AT deficiency is an autosomal not recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant retain polymerised protein in the endoplasmic reticulum of hepatocytes, predisposing them to liver disease. This study primarily aimed to uncover the molecular mechanisms t...
ORGANISM(S): Homo sapiens 
2018-06-26 | E-MTAB-6781 | biostudies-arrayexpress
TranscriptomicsAltered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression
Alternative polyadenylation results in different 3’ isoforms of messenger RNA (mRNA) transcripts. Alternative polyadenylation in the 3’ untranslated region (3’UTR) can alter RNA localization, stability and translational efficiency. The SERPINA1 mRNA has two distinct 3’ UTR isoforms, both of which ex...
ORGANISM(S): Homo sapiens 
2025-03-01 | GSE277810 | GEO
UnknownA1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis.
Not available
S-EPMC11873038 | biostudies-literature
GenomicsAltered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression
Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression
PRJNA1164250 | ENA
UnknownInvestigation of CCL18 and A1AT as potential urinary biomarkers for bladder cancer detection.
Not available
S-EPMC3846766 | biostudies-literature
GenomicsHomo sapiens
Role of A1AT in human edometrial stromal cells
PRJDB11905 | ENA
GenomicsRNA-seq of hepatocytes obtained through step-wise differentiation of hIPSCs from a patient with A1AT deficiency and its point mutation-corrected isogenic hIPSC line. Comparison to primary hepatocytes from a healthy donor and an A1AT-deficient patient.
RNA-seq of hepatocytes obtained through step-wise differentiation of hIPSCs from a patient with A1AT deficiency and its point mutation-corrected isogenic hIPSC line. Comparison to primary hepatocytes from a healthy donor and an A1AT-deficient patient.
PRJEB27377 | ENA
ProteomicsLabel-free quantitative proteomics reveals aberrant expression levels of LRG, C9, FN, A1AT and AGP in the plasma of patients with colorectal cancer
Background: Colorectal cancer (CRC) is one of the major causes of cancer-related death worldwide. Although commercial biomarkers of CRC are currently available, they are still lacking in terms of sensitivity and specificity; thus, searching for reliable blood-based biomarkers are important for the p...
ORGANISM(S): Homo sapiens (Human) 
2023-03-29 | PXD040999 | Pride
Blood-based biomarkers Mars-14 Label-free quantitative proteomics Affinity chromatography Colorectal cancer 
GenomicsHomo sapiens
Role of A1AT in human trophoblast
PRJDB11906 | ENA
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