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TranscriptomicsNuclear Matrix Association in Proliferative and Invasive Cytotrophoblasts
Abnormal trophoblast invasion is associated with the most common and most severe complications of human pregnancy. The biology of invasion, as well as the etiology of abnormal invasion remains poorly understood. The aim of this study was to characterize the transcriptome of the HTR-8/SVneo human c...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-17501 | biostudies-arrayexpress
ProteomicsLabel-free quantitative proteomics reveals aberrant expression levels of LRG, C9, FN, A1AT and AGP in the plasma of patients with colorectal cancer
Background: Colorectal cancer (CRC) is one of the major causes of cancer-related death worldwide. Although commercial biomarkers of CRC are currently available, they are still lacking in terms of sensitivity and specificity; thus, searching for reliable blood-based biomarkers are important for the p...
ORGANISM(S): Homo sapiens (Human) 
2023-03-29 | PXD040999 | Pride
Blood-based biomarkers Mars-14 Label-free quantitative proteomics Affinity chromatography Colorectal cancer 
ProteomicsQuantitative proteomic analysis of fresh-frozen human breast tissue and tumor samples using microLC-SWATH-MS
Future improvements in the field of breast cancer prevention, diagnosis and treatment require deeper knowledge and better understanding of the molecular processes and signaling pathways that lead to the transformation of normal cells to cancer ones and the disease progression. Quantitative proteome ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD008408 | Pride
Breast tissue Fresh frozen Breast tumor Microlc Swath-ms Quantitative proteomics 
ProteomicsHuman serum samples - Acute and chronic blood serum proteome changes in patients with methanol poisoning
We carried out a prospective, longitudinal, single-center, observational cohort study of patients with confirmed acute methanol poisoning that were treated in hospitals during a mass methanol poisoning outbreak in the Czech Republic in 2012. Venous blood for proteomic analysis was obtained from 24 p...
ORGANISM(S): Homo sapiens (Human) 
2022-12-12 | PXD035726 | Pride
Lc-ms/ms Human Acute poisoning Serum Methanol 
ProteomicsOmics Reveal Far Reaching Effects of Verapamil Treatment in Subjects with Type 1 Diabetes
Proteomic data from recent onset T1D patients treated with verapamil where significant extension of the honeymoon phase was observed. Samples were depleted with MARS Hu-14 column, digested with trypsin, labeled with 11-plex TMT, then analyzed by LC-MS/MS. Data was searched with MS-GF+ using PNNL's D...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-06-09 | MSV000087598 | MassIVE
TranscriptomicsNuclear Matrix Association in Proliferative and Invasive Cytotrophoblasts
Abnormal trophoblast invasion is associated with the most common and most severe complications of human pregnancy. The biology of invasion, as well as the etiology of abnormal invasion remains poorly understood. The aim of this study was to characterize the transcriptome of the HTR-8/SVneo human cyt...
ORGANISM(S): Homo sapiens 
2010-06-22 | GSE17501 | GEO
ProteomicsCSF proteome mapping: Human cerebrospinal fluid LC-MS/MS, Part 2
3 mL CSF from a pool of 21 neurologically healthy donors was separated into a bound and a depleted fraction using a MARS Hu-14 column. This experiment represents the depleted fraction. Gel separation on a gradient gel (SDS-PAGE) followed and the gel lane was cut into 46 fractions. Each fraction was ...
ORGANISM(S): Homo sapiens (Human) 
2014-08-04 | PXD000652 | Pride
Homo sapiens Cerebrospinal fluid Lc-ms/ms 
ProteomicsCSF proteome mapping: Human cerebrospinal fluid LC-MS/MS, Part 1
3 mL CSF from a pool of 21 neurologically healthy donors was separated into a bound and a depleted fraction using a MARS Hu-14 column. This experiment represents the bound fraction. Gel separation on a gradient gel (SDS-PAGE) followed and the gel lane was cut into 37 fractions. Each fraction was in-...
ORGANISM(S): Homo sapiens (Human) 
2014-08-04 | PXD000651 | Pride
Homo sapiens Cerebrospinal fluid Lc-ms/ms 
ProteomicsCSF proteome mapping: Human plasma LC-MS/MS, Part 7
40 µL plasma from a pool of 20 neurologically healthy donors was separated into a bound and a depleted fraction using a MARS Hu-14 column. This experiment represents the depleted fraction. Sample was in-solution trypsin digested and peptides were fractionated into 67 fractions by mixed-mode reversed...
ORGANISM(S): Homo sapiens (Human) 
2014-08-04 | PXD000657 | Pride
Plasma Homo sapiens Lc-ms/ms 
ProteomicsCSF proteome mapping: Human cerebrospinal fluid LC-MS/MS, Part 4
1.6 mL CSF from a pool of 21 neurologically healthy donors was separated into a bound and a depleted fraction using a MARS Hu-14 column. This experiment represents the depleted fraction. Sample was in-solution trypsin digested and resulting peptides were fractionated into 66 fractions by mixed-mode ...
ORGANISM(S): Homo sapiens (Human) 
2014-08-04 | PXD000654 | Pride
Homo sapiens Cerebrospinal fluid Lc-ms/ms 
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