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MetabolomicsBridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC–HRMS in a Single Run for Sensitive Exposomics

Traditionally, chemical exposure has been assessed by low-resolution mass spectrometry via targeted approaches due to the typically extremely low concentration of such compounds in biological samples. Nevertheless, untargeted approaches are now becoming a promising tool for a broader investigatio...

2025-08-28 | MTBLS10565 | MetaboLights
ProteomicsSWATH-MS identification of CXCL7, LBP, TGFβ1 and PDGFRβ as novel biomarkers in human systemic mastocytosis.
We carried out a novel clinical biomarker investigation of the blood of systemic mastocytosis patients versus healthy controls; utilizing a new and emerging technology platform Sequential Window Acquisition of all Theoretical fragment-ion spectra mass spectrometry (SWATH-MS). This is the first use ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030947 | Pride
Mastocytosis Swath-ms Biomarkers 
ProteomicsA comprehensive CHO SWATH-MS spectral library for accurate quantitative profiling of 10k proteins
A comprehensive Chinese hamster ovary (CHO)-cell specific spectral library, containing extensive information of high-quality spectral ions covering more than 10k CHO cell proteins, was constructed to provide confident and reproducible protein identification and quantification in data-independent SWA...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2020-07-20 | PXD016047 | Pride
Tripletof 6600 Swath-ms Chinese hamster ovary cells Lc-ms/ms 
ProteomicsAssessing Technical and Biological Variation in SWATH-MS -based Proteomics: A case study in Chronic Lymphocytic Leukaemia
Chronic lymphocytic leukaemia (CLL) is renowned for its variable clinical course and response to therapy, suggesting a role for precision medicine. However, the molecular basis of CLL variability remains incompletely understood. Recent developments in data independent acquisition (DIA) -MS technolog...
ORGANISM(S): Homo sapiens (Human) 
2021-02-08 | PXD011330 | Pride
Cll Swath Leukaemia 
ProteomicsA mouse SWATH-MS reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts
SWATH-MS enables accurate and reproducible label-free quantification of proteomes including in extensively studied model organisms such as the mouse. Here we present a comprehensive mouse reference spectral library (MouseRefSWATH) that allows quantification of up to 10,597 proteins (62.2% of mouse p...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-06-23 | PXD017209 | Pride
Swath-ms  breast cancer  dcis  mouse  human  xenograft model 
ProteomicsQuantitative proteomic analysis of fresh-frozen human breast tissue and tumor samples using microLC-SWATH-MS
Future improvements in the field of breast cancer prevention, diagnosis and treatment require deeper knowledge and better understanding of the molecular processes and signaling pathways that lead to the transformation of normal cells to cancer ones and the disease progression. Quantitative proteome ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD008408 | Pride
Breast tissue Fresh frozen Breast tumor Microlc Swath-ms Quantitative proteomics 
ProteomicsSWATH-MS based characterization for proteome profile data of chemicals
Profile data analysis is useful to reveal the mode of action of low molecular weight compounds. Although transcriptome data have been the main target of the profile data analysis, it is unknown whether omics data in different layers could deserve the profile data analysis. In the first place, what i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-22 | PXD032785 | Pride
Mcf7 Olsa New mode of action Swath-ms 
ProteomicsThe Pan-Human Library: A repository of assays to quantify 10 000 proteins by SWATH-MS / SWATH-MS validation data
The “Pan-Human Library” is a compendium of highly specific assays covering more than 10 000 human proteins and enabling their targeted analysis in SWATH-MS datasets acquired from research or clinical specimens. This dataset contains validation SWATH-MS data and OpenSWATH results of whole cell lysate...
ORGANISM(S): Homo sapiens (Human) 
2014-08-08 | PXD000954 | Pride
Human Openswath Swath Swath-ms Targeted proteomics Pan-human library 
ProteomicsSWATH-MS Analysis of Striatal Synaptic Mitochondria from Pink1 KO rats
This study investigates the proteomic alterations in striatal synaptic mitochondria isolated from 3-month-old wild-type and Pink1 KO rats using the SWATH-MS strategy. This dataset consists of 32 raw MS files, comprising 8 DIA (SWATH) and 24 DDA runs on a TripleTOF 5600 (SCIEX). Our findings revealed...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-09-28 | PXD004558 | Pride
Swath-ms Mitochondria Parkinson's disease 
ProteomicsGlobal proteome rearrangement screen in interphasic and mitotic HeLa CCL2 cell line by SEC-SWATH-MS
It has become increasingly clear that biological functions depend not only on the identity and quantity, but also the correct interplay among the biomolecules that constitute the cell. Importantly, proteins as the key effectors in the cell dynamically organize into complexes. This study describes a ...
ORGANISM(S): Homo sapiens (Human) 
2019-05-10 | PXD010288 | Pride
Human Protein-protein complexes Hela Cell cycle Swath-ms Sec Mitosis 
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