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ProteomicsA2ML1's and A2M's reactivity towards glycine and glycerol, A2ML1 crosslinking to thermolysin
A2ML1 (wildtype and H1084N) and A2M (wildtype and N1088H) were activated by chymotrypsin, allowing their thiol ester to react with protease, water, or the added substrates glycerol or glycine.
ORGANISM(S): Homo sapiens (Human) 
2020-09-25 | PXD020826 | Pride
Thiol ester Protease inhibitor A2ml1 A2m 
UnknownRare A2ML1 variants confer susceptibility to otitis media.
Not available
S-EPMC4528370 | biostudies-literature
UnknownA2ML1 and otitis media: novel variants, differential expression, and relevant pathways.
Not available
S-EPMC6711784 | biostudies-literature
UnknownHuman PZP and common marmoset A2ML1 as pregnancy related proteins.
Not available
S-EPMC7083932 | biostudies-literature
UnknownThe clinical significance of A2ML1 variants in Noonan syndrome has to be reconsidered.
Not available
S-EPMC7940614 | biostudies-literature
UnknownCryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Not available
S-EPMC9156758 | biostudies-literature
UnknownHeterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome.
Not available
S-EPMC4326711 | biostudies-literature
ProteomicsA2ML1 bait region mapping and glycan determination
See article for descriptions of the purposes, methods, and results.
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD032010 | Pride
Protease inhibitor A2ml1 
Unknownα2-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester.
Not available
S-EPMC7864068 | biostudies-literature
UnknownTranscriptional Profiling of Human Peripheral Blood Mononuclear Cells Identifies Diagnostic Biomarkers That Distinguish Active and Latent Tuberculosis.
Not available
S-EPMC6930242 | biostudies-literature
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