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ProteomicsMass spectrometry analysis of post-translational modifications of K/C-III-expressing HEK293T cells treated by A485 for 6 and 12 hours
To determine whether CBP/P300 HAT activity is essential for leukemia cell maintenance, we utilized the selective acetyltransferase inhibitor A485. Mass spectrometry analysis of post-translational modifications showed that A485 treatment of K/C-III-expressing HEK293T cells for 6 and 12 hours signific...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD061565 | Pride
Human A485 Post-translational modification K/c-iii Lc-faims-ms/ms 
GenomicsRNA-seq profiling of WT and LKB1 knockout mouse embryonic fibroblasts treated with the HAT inhibitor A485
RNA-seq profiling of WT and LKB1 knockout mouse embryonic fibroblasts treated with the HAT inhibitor A485
PRJNA945063 | ENA
TranscriptomicsRNA-seq profiling of WT and LKB1 knockout mouse embryonic fibroblasts treated with the HAT inhibitor A485
Investigating transcriptional profile of WT and LKB1 knockout mouse embryonic fibroblasts untreated, stimulated with IL-1β, treated with A485 alone, or stimulated with IL-1β and A485
ORGANISM(S): Mus musculus 
2023-05-11 | GSE227446 | GEO
UnknownTargeting EP300 in diffuse large b-cell lymphoma: efficacy of A485 and synergistic effects with XPO1 inhibition.
Not available
S-EPMC12117677 | biostudies-literature
UnknownSmall-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response.
Not available
S-EPMC10923082 | biostudies-literature
GenomicsOncohistone mutations occur at functional sites of regulatory ADP-ribosylation: the role of oncohistone mutations in transcriptional regulation [ChIP-Seq]
H2BK12ac ChIP-seq were performed in MDA-MB-231 cells ectopically expressing FLAG-tagged WT, D51A, or D51N H2B ± treatment with A485 (5 M, 2 hours) or vehicle (DMSO).
ORGANISM(S): Homo sapiens 
2022-08-02 | GSE180459 | GEO
UnknownAcetylated-PPARγ expression is regulated by different P53 genotypes associated with the adipogenic differentiation of polyploid giant cancer cells with daughter cells.
Not available
S-EPMC9843444 | biostudies-literature
UnknownSchistosomicidal effects of histone acetyltransferase inhibitors against Schistosoma japonicum juveniles and adult worms in vitro.
Not available
S-EPMC11361729 | biostudies-literature
GenomicsSynergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit. [Cut & Run]
Rhabdomyosarcoma (RMS) is a high-risk and lethal pediatric sarcoma that resembles developing skeletal muscle. RMS tumors have a low mutation burdens, though but these scant mutations contain mutations inalter genes involved in transcriptional control. Transcriptional dysregulation is critical to RMS...
ORGANISM(S): Homo sapiens 
2026-09-28 | GSE347491 | GEO
GenomicsSynergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit [ChIP-Seq]
Rhabdomyosarcoma (RMS) is a high-risk and lethal pediatric sarcoma that resembles developing skeletal muscle. RMS tumors have a low mutation burdens, though but these scant mutations contain mutations inalter genes involved in transcriptional control. Transcriptional dysregulation is critical to RMS...
ORGANISM(S): Homo sapiens 
2026-09-28 | GSE307450 | GEO
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