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TranscriptomicsSMAD3 targets in A549 lung epithelial cells
TGF? activates a signal transduction cascade that results in the transcription of genes, primarily through the DNA-binding transcription factor SMAD3. The objective of this study is to identify SMAD3 binding targets and the molecular pathways affected by the TGF?1/SMAD3 signal transduction on a geno...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-26858 | biostudies-arrayexpress
MetabolomicsA549 13C-labeled Cell Study
Not available
ORGANISM(S): Homo sapiens 
ST000148 | MetabolomicsWorkbench
ProteomicsUninfected and human respiratory syncytial virus (RSV)-infected A549 cells, analysed using bottom-up mass spectrometry
Proteomic data from uninfected and human respiratory syncytial virus (RSV) infected A549 cells (24h post infection; four biological replicate sets). Data is related to the fractionation-free workflow described in Dave et al. (2014) (PMID: 25106423). Data is processed using MaxQuant (version 1.3.0.5)...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Respiratory Syncytial Virus A2 (ncbitaxon:11259) 
2016-08-08 | MSV000080032 | MassIVE
ProteomicsThe proteomic analysis of human lung epithelial cells exposed with or without radon
Human lung epithelial A549 cells were exposed to radon 1,000 Bq/m3 for 30 min, repeated daily for seven days. The control cells were cultured under the same conditions but without radon exposure. Cells were washed three times with ice-cold 1x phosphate buffer saline supplemented with protease inhibi...
ORGANISM(S): Homo Sapiens (human) 
2025-03-18 | PXD058364 | JPOST Repository
ProteomicsUninfected and human respiratory syncytial virus (RSV)-infected A549 cells, analysed using in-solution protein IEF followed by bottom-up mass spectrometry
Proteomic data from uninfected and human respiratory syncytial virus (RSV)-infected A549 cells (24h post infection; five paired biological replicate sets). Data is related to the in-solution protein IEF workflow described in Dave et al. (2014) (PMID: 25106423). Data processed using MaxQuant (version...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Respiratory Syncytial Virus A2 (ncbitaxon:11259) 
2016-01-12 | MSV000079453 | MassIVE
TranscriptomicsMolecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis.
This study proposes a molecular mechanism for lung epithelial A549 cell response to copper oxide nanoparticles (CuO-NPs) related to Cu ions released from CuO-NPs. Cells that survived exposure to CuO-NPs arrested the cell cycle as a result of the downregulation of proliferating cell nuclear antigen (...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-33278 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Streptococcus pneumoniae after incubation with host respiratory tract epithelial cells
In order to study pneumococcal gene expression changes after incubation with host epithelial cells, logarithmic-phase grown S. pneumoniae strains (82 and R6) were incubated with host epithelial cells (A549 and ETEC) in T75 cell culture flasks at an MOI range of 10:1 ~ 50:1. After incubation for 1 h ...
ORGANISM(S): Streptococcus pneumoniae 
2008-05-07 | E-TABM-187 | biostudies-arrayexpress
TranscriptomicsGene expression profile of A549 cells from tissue of 4D model predicts poor prognosis in lung cancer patients
Tumor microenvironment plays an important role in regulating cell growth and metastasis. Recently we developed an ex vivo lung cancer model (4D) that forms perfusable tumor nodules on a lung matrix that mimics human lung cancer histopathology and protease secretion pattern. We compared the gene ex...
ORGANISM(S): Homo sapiens 
2013-09-16 | E-GEOD-45142 | biostudies-arrayexpress
TranscriptomicsEts homologous factor regulates pathways controlling response to injury in Calu-3 airway epithelial cells [RNA-seq]
Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithelial cell types including those lining the respiratory system. Disruption of the airway epithelium is central to many lung diseases, and a network of transcription factors coordinates its normal function. EHF c...
ORGANISM(S): Homo sapiens 
2014-12-23 | E-GEOD-63397 | biostudies-arrayexpress
MetabolomicsComparative analysis of the adaptation of Staphylococcus aureus to internalization by different types of human non-professional phagocytic host cells (NMR assay)
Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival an...
2015-07-01 | MTBLS102 | MetaboLights
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