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TranscriptomicsThe outer mitochondrial membrane AAA ATPase AtOM66 affects cell death and pathogen resistance in Arabidopsis thaliana
3 week old AtOM66 overexpression and knockout plants were compared to wild type Col-0 plants during a drought stress time course. Samples were taken 2 days after last watering (untreated), 9 days (early drought) and 11 days (late drought).
ORGANISM(S): Arabidopsis thaliana 
2014-10-30 | E-MTAB-3044 | biostudies-arrayexpress
ProteomicsUbiquitin-independent disassembly by a p97 AAA-ATPase complex drives PP1 holoenzyme formation
Protein phosphatase-1 (PP1) dephosphorylates a broad spectrum of substrates to regulate a myriad of cellular processes. This functional diversity relies on the ordered assembly of alternative PP1 holoenzymes. Here, we show that newly synthesized PP1 is first held in an inactive complex by its partne...
ORGANISM(S): Homo sapiens (Human) 
2018-10-23 | PXD010750 | Pride
Protein phosphatase-1  protein biogenesis  aaa atpase  vcp/p97  ubiquitin  protein unfolding 
TranscriptomicsRNAi knock down of VCP in human HeLa cells
Study of the effects of the VCP knockdown. VCP (p97, yeast cdc48) is a hexameric AAA ATPase involved in various cellular functions including degradation of proteins by the ubiquitin-proteasome system. We examine the consequences of the reduction of VCP levels after RNAi of VCP in HeLa cells. We find...
ORGANISM(S): Homo sapiens 
2006-08-23 | E-MEXP-817 | biostudies-arrayexpress
ProteomicsVisualization of the Cdc48 AAA+ ATPase protein unfolding pathway: Substrate Identification
The Cdc48 AAA+ ATPase is an abundant and essential enzyme that unfolds substrates in multiple protein quality control pathways. The enzyme includes two conserved AAA+ ATPase cassettes, D1 and D2, that assemble as hexameric rings with D1 stacked above D2. Here, we report an ensemble of structures of ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-10-17 | PXD048280 | Pride
Human Shp1 pulldown 
ProteomicsStructure of the AAA-ATPase Drg1 during extraction of Rlp24 from pre-60S particles
The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large ribosomal subunit. Drg1 releases the shuttling maturation factor Rlp24 from pre-60S particles shortly after nuclear export, a strict requirement for downstream maturation. The mol...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-14 | PXD032098 | Pride
Large ribosomal subunit Ribosome biogenesis Aaa-atpases Substrate recognition Substrate translocation mechanism Single particle cryo-em 
ProteomicsStoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry
AAA+ ATPases constitute a large family of proteins that are involved in a plethora of cellular processes including DNA disassembly, protein degradation and protein complex disassembly. They typically form a hexametric ring-shaped structure with six subunits in a (pseudo) six-fold symmetry. In a subs...
ORGANISM(S): Methanocaldococcus Jannaschii 
2020-03-25 | MSV000085155 | MassIVE
TranscriptomicsFunctional cooperation between AAA-ATPase domain and a bromodomain.
A functional cooperation between an AAA type ATPase domain and a bromodomain has been evidenced. These two domains were identified and their activity tested in a yet uncharacterized factor, named Atad2, whose two-domain configuration remained highly conserved during evolution. In human and mouse, At...
ORGANISM(S): Homo sapiens 
2009-10-01 | GSE12279 | GEO
ProteomicsER-stress-induced_transcription
A conserved AAA+ ATPase network regulates ER-stress-induced transcription
ORGANISM(S): Caenorhabditis Elegans (c. Elegans) 
2015-12-31 | PAe005594 | PeptideAtlas
UnknownA concerted ATPase cycle of the protein transporter AAA-ATPase Bcs1.
Not available
S-EPMC10567702 | biostudies-literature
UnknownInterprotomer motion-transmission mechanism for the hexameric AAA ATPase p97.
Not available
S-EPMC3309748 | biostudies-literature
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