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TranscriptomicsDual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model
Analyses of differential gene expression analyses from intact versus castrated Nkx3.1CE2/+ or Nkx3.1CE2/+; Ptenf/f mice Total RNA isolated form phenotypically wild-type (intact) Nkx3.1CE2/+ (n = 3), intact Nkx3.1CE2/+; Ptenf/f (n = 6), and castrated Nkx3.1CE2/+; Ptenf/f (n = 6) prostate. Please con...
ORGANISM(S): Mus musculus 
2012-07-03 | E-GEOD-39054 | biostudies-arrayexpress
TranscriptomicsLineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell of origin model for prostate cancer heterogeneity
We used RNA-seq to compare the expression profiles of mouse prostate tumors originated from epithelial basal cells to those originated from luminal cells. We next generated expression signatures for both basal and luminal origin tumors by comparison of tumor samples to their respective controls. By ...
ORGANISM(S): Mus musculus 
2013-01-14 | E-GEOD-39509 | biostudies-arrayexpress
TranscriptomicsB-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer
Anaysis of the response to different therapeutic agents at the transcriptional level. The design of the experiment allows to determine how the comnination target therapy (Rapamycin + PD0325901) treatment shifted the transcriptome towards a less aggressive or even a wild type phenotype. It also allow...
ORGANISM(S): Mus musculus 
2012-07-18 | E-GEOD-39190 | biostudies-arrayexpress
UnknownItalian multicentre observational study of the prevalence of CCSVI in multiple sclerosis (CoSMo study): rationale, design, and methodology.
Not available
S-EPMC3747324 | biostudies-literature
TranscriptomicsCross-species analysis of genome-wide regulatory networks identifies a synergistic dependency between FOXM1 and CENPF that drives prostate cancer malignancy
Analysis of the transcriptome of mouse models of prostate cancer to assemble a mouse prostate cancer interactome. To assemble the mouse prostate cancer interactome, we collected 13 distinct mice or genetically-engineered mouse models (GEMMs), which together represent the full spectrum of prostate ca...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-53202 | biostudies-arrayexpress
TranscriptomicsPredicting drug response in human prostate cancer from preclinical analysis of in vivo mouse models (II)
Analysis of the transcriptome of allografted mouse tumors after treatment with rapamycin and PD0325901. Nkx3.1CreERT2/+; Ptenflox/flox; KrasLSL-G12D/+ (NPK mice) were induced and their tumors removed to generate allograft lines by implanting a 1.5 mm3 tumor fragment in the subcutaneous space of athy...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-69213 | biostudies-arrayexpress
TranscriptomicsPredicting drug response in human prostate cancer from preclinical analysis of in vivo mouse models (I)
Analysis of the transcriptome of mouse models of prostate cancer after treatment with rapamycin and PD0325901 combination therapy or standard of care docetaxel. The Nkx3.1CreERT2/+; Ptenflox/flox; KrasLSL-G12D/+ (NPK mice) was used in this study. Two months after tumor induction, mice were randomly ...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-69211 | biostudies-arrayexpress
UnknownMultiple sclerosis from onset to secondary progression: a 30-year Italian register study.
Not available
S-EPMC12573403 | biostudies-literature
TranscriptomicsETV4 promotes metastasis in response to combined activation of PI3kinase and RAS signaling in a mouse model of advanced prostate cancer
Analysis of the transcriptome of mouse models of prostate cancer. NP (Nkx3.1CreERT2/+; Ptenfloxed/floxed) mice develop non-metastatic tumors while NPK (Nkx3.1CreERT2/+; Ptenfloxed/floxed; KrasG12D/+) mice develop metastatic tumors The NPK mice are also analyzed at early and late stages of tumorigene...
ORGANISM(S): Mus musculus 
2013-07-23 | E-GEOD-47697 | biostudies-arrayexpress
UnknownSativex in resistant multiple sclerosis spasticity: Discontinuation study in a large population of Italian patients (SA.FE. study).
Not available
S-EPMC5538735 | biostudies-literature
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