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TranscriptomicsGenetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma
Asthma is caused by a combination of poorly understood genetic and environmental factors. We found multiple markers on chromosome 17q21 to be strongly and reproducibly associated with childhood onset asthma in family and case-referent panels with a combined P < 10-12. In independent replication stu...
ORGANISM(S): Homo sapiens 
2007-11-09 | E-GEOD-8052 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skin from psoriatic patients and normal controls
Gene expression has been proposed as an intermediate phenotype that can increase power in complex trait gene-mapping studies. Psoriasis, an immune-mediated, inflammatory and hyperproliferative disease of the skin and joints, provides an ideal model system to evaluate this paradigm, as conclusive evi...
ORGANISM(S): Homo sapiens 
2009-02-01 | E-GEOD-13355 | biostudies-arrayexpress
TranscriptomicsMRCA expression
We have created a global map of the effects of polymorphism on gene expression in 400 children from families recruited through a proband with asthma. We genotyped 408,273 SNPs and identified expression quantitative trait loci from measurements of 54,675 transcripts representing 20,599 genes in Epste...
ORGANISM(S): Homo sapiens 
2013-01-09 | E-MTAB-1425 | biostudies-arrayexpress
TranscriptomicsMRCE expression
We have created a global map of the effects of polymorphism on gene expression in 550 children from families recruited through a proband with atopic dermatitis. We genotyped >300,000 SNPs and identified expression quantitative trait loci from measurements of 16,487 probes representing 15,576 genes i...
ORGANISM(S): Homo sapiens 
2013-01-09 | E-MTAB-1428 | biostudies-arrayexpress
UnknownA Scalable Bayesian Method for Integrating Functional Information in Genome-wide Association Studies.
Not available
S-EPMC5590971 | biostudies-literature
GenomicsMRCA_300K - samples
MRCA sample using 300K
EGAD00010000385 | EGA
GenomicsMRCA_100K - samples
MRCA sample using 100K
EGAD00010000383 | EGA
GenomicsMRCE_300K - samples
MRCE sample using 300K
EGAD00010000381 | EGA
GenomicsMRCA and MRCE SNP genotypes
Gene expression levels can be an important link DNA between variation and phenotypic manifestations. Our previous map of global gene expression based on approximately 400K SNPs and 50K transcripts in 400 sib pairs from the MRCA family panel has been widely used to interpret the results of GWAS. Here...
EGAS00000000137 | EGA
GenomicsAge related Macular Degeneration (AMD)-- Michigan, Mayo, AREDS, Pennsylvania (MMAP) Cohort Study: A Joint Genome Wide Association Study

Age-related Macular Degeneration (AMD) is a leading cause of incurable blindness in people over the age of 65. AMD is a late-onset multi-factorial neurodegenerative disease and its pathogenesis involves interaction of genetic and environmental factors. Several chromosomal regions have been as...

phs000182.v2.p1 | EGA
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