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TranscriptomicsEffect of Lithium on Abeta utilising microarray analyses
Our previous work in a Drosophila model of Alzheimer's disease (AD) has shown that we can intervene into the pathways to slow or prevent AD progression. Lithium was able to rescue toxicity in the Drosophila AD model which corresponded with a reduction in Abeta levels. Furthermore, we have demonstra...
ORGANISM(S): Drosophila melanogaster 
2017-01-26 | E-MTAB-4611 | biostudies-arrayexpress
TranscriptomicsAbeta-activated Array Experiment
This series represents the samples used to generate the associated gene listing. The samples contained belong to two Platform accessions GPL561 and GPL562. There is a slight redundancy in the gene list due to multiple strong hits for a given gene. Clone selection was based on a fold >= 1.2 with a p-...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-772 | biostudies-arrayexpress
TranscriptomicsChanges of axonal transcriptomes in response to local Abeta
We report that local application of Abeta(1-42) for 24h triggers changes in the localized transcriptome, while the transcriptome in cell bodies remains largely unchanged. Axonal and somatic mRNA profiles of rat embryonic hippocampal neurons grown in microfluidic chambers were generated by RNA-Seq in...
ORGANISM(S): Rattus norvegicus 
2015-07-14 | E-GEOD-70860 | biostudies-arrayexpress
TranscriptomicsAbeta levels in APP Tg mice with mixed genetic backgrounds
We combined a mouse model of Abeta accumulation and transcriptomics, and identified Klc1 as an Abeta accumulation modifier in vivo.
ORGANISM(S): Mus musculus 
2014-01-15 | GSE40330 | GEO
TranscriptomicsAbeta levels in APP Tg mice with mixed genetic backgrounds
We combined a mouse model of Abeta accumulation and transcriptomics, and identified Klc1 as an Abeta accumulation modifier in vivo. For this transcriptomics analysis, we used 12 arrays (one mouse mRNA sample per array) for inbred mice analyses and 28 arrays for the APP Tg mice of mixed genetic backg...
ORGANISM(S): Mus musculus 
2014-01-15 | E-GEOD-40330 | biostudies-arrayexpress
TranscriptomicsHippocampal gene expression profiling of a model of Alzheimer`s Disease upon treatment with the ACE inhibitor captopril
Extracellular senile plaques of amyloid beta (Abeta) are a pathological hallmark in brain of patients with Alzheimer`s Disease (AD). Abeta is generated by the amyloidogenic processing of the amyloid precursor protein (APP). Concomitant to Abeta load, AD brain is characterized by an increase in prote...
ORGANISM(S): Mus musculus 
2013-05-14 | E-GEOD-46871 | biostudies-arrayexpress
UnknownAmyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways.
Not available
S-EPMC140968 | biostudies-literature
UnknownSmall molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity.
Not available
S-EPMC2637905 | biostudies-literature
TranscriptomicsChanges of axonal transcriptomes in response to local Abeta
We report that local application of Abeta(1-42) for 24h triggers changes in the localized transcriptome, while the transcriptome in cell bodies remains largely unchanged.
ORGANISM(S): Rattus norvegicus 
2015-07-14 | GSE70860 | GEO
UnknownComparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures.
Not available
S-EPMC2764733 | biostudies-literature
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