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UnknownAmyloid beta protein: Abeta40 inhibits Abeta42 oligomerization.
Not available
S-EPMC2697393 | biostudies-literature
ProteomicsThe HSP40 chaperone Ydj1/DnaJA1 drives amyloid beta toxicity
Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD); however, the etiology of Abeta42 toxicity remains elusive. In a proteomic approach using a yeast model for intracellular Abeta42 toxicity, we here identify the HSP40 family member Ydj1, the yeast...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-04-27 | PXD012612 | Pride
Lc-ms/ms Alzheimer’s disease Yeast Saccharomyces cerevisiae Silac 
UnknownInhibition of Abeta42 aggregation using peptides selected from combinatorial libraries.
Not available
S-EPMC2807629 | biostudies-literature
UnknownInhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.
Not available
S-EPMC2593882 | biostudies-literature
UnknownAbeta42 is essential for parenchymal and vascular amyloid deposition in mice.
Not available
S-EPMC1373682 | biostudies-literature
TranscriptomicsTranscription profiling of SH-SY5Y cells after treatment with soluble Abeta42_wt, Abeta42_G33A and Abeta40 for different timepoints
Although amyloid-beta42 (Abeta42) has long been implicated in the pathogenesis of Alzheimer disease (AD), the biological basis of its effects remains uncertain. Intraneuronal Abeta accumulation in brains of patients with AD or Down syndrome, in animal models, and in cultured cells has suggested an e...
ORGANISM(S): Homo sapiens 
2014-12-01 | E-MTAB-1841 | biostudies-arrayexpress
UnknownThe ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.
Not available
S-EPMC2661389 | biostudies-literature
UnknownGxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.
Not available
S-EPMC1829382 | biostudies-literature
UnknownOpposite effects of low and high doses of Abeta42 on electrical network and neuronal excitability in the rat prefrontal cortex.
Not available
S-EPMC2791225 | biostudies-literature
UnknownDissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease.
Not available
S-EPMC404095 | biostudies-literature
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