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Attention to exploring endothelial cell (EC) metabolism is increasing, but a holistic perspective on the metabolic adaptations of ECs during angiogenic proliferation, is still missing. Here, we use a previously in-house developed computational EC-adapted genome scale metabolic model that recapitulat...
2026-08-10 | MTBLS15306 | MetaboLights
In this study, we discover an essential role for the mitochondrial glutamate-aspartate antiporter SLC25A13 in biomass synthesis in endothelial cells (ECs). To delineate the global changes of SLC25A13 silencing at a molecular level, we performed high-throughput bulk RNA-sequencing and analyzed the di...
ORGANISM(S): Homo sapiens 
The uploaded model is linked to the Scientific Reports article: Subramanian, A., Sarkar, R.R. Revealing the mystery of metabolic adaptations using a genome scale model of Leishmania infantum . Sci Rep 7, 10262 (2017). https://doi.org/10.1038/s41598-017-10743-x. Human macrophage phagolysosome and san...
2020-10-13 | MODEL2010130001 | BioModels
The uploaded model is linked to the PLoS ONE article: Subramanian A, Jhawar J, Sarkar RR (2015) Dissecting Leishmania infantum Energy Metabolism - A Systems Perspective. PLoS ONE 10(9): e0137976. https://doi.org/10.1371/journal.pone.0137976. The reconstructed network consists of 142 genes encoding f...
2020-10-13 | MODEL2010130002 | BioModels
Sengupta2015 - Knowledge base model of human energy pool network (HEPNet) This model is described in the article: HEPNet: A Knowledge Base Model of Human Energy Pool Network for Predicting the Energy Availability Status of an Individual. ...
2024-09-02 | BIOMD0000000579 | BioModels
As a preliminary step towards applying next generation sequencing using neurons derived from patient-specific iPSCs, we have carried out an RNA-Seq analysis on control human neurons. Dramatic changes in the expression of coding genes, long non-coding RNAs (lncRNAs), pseudogenes, and splice isoforms ...
ORGANISM(S): Homo sapiens 
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