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ProteomicsDuplicated ribosomal protein paralogs promote alternative translation and drug resistance
Ribosomes are often seen as monolithic machines produced from uniformly regulated genes. However, in yeast most ribosomal proteins come from duplicated genes. Here, we demonstrate that gene duplication may serve as a stress-adaptation mechanism modulating the global proteome through the differential...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-09 | PXD033843 | Pride
Drpg Saccharomyces cerevisiae Paralogs 
ProteomicsTranscription factors induce differential splicing of duplicated ribosomal protein genes during meiosis
In Saccharomyces cerevisiae, most ribosomal proteins are produced from duplicated genes. These nearly identical protein pairs are expressed at varying levels, with one ‘major paralog’ usually predominating. The minor paralog is highly transcribed but held in check through reduced intron removal, but...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-12-20 | PXD050249 | Pride
Splicing Ribosomal proteins Yeast 
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