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ProteomicsRetargeting from CR3 to the LFA-1 receptor uncovers the adenylyl cyclase enzymetranslocating segment of Bordetella adenylate cyclase toxin
The Bordetella adenylate cyclase toxinhemolysin (CyaA) and the α-hemolysin (HlyA) of Escherichia coli both belong to the family of cytolytic pore-forming Repeats in ToXin (RTX) cytotoxins. HlyA preferentially binds the αLβ2 integrin LFA-1 (CD11a/CD18) of leukocytes and can promiscuously bind and per...
ORGANISM(S): Escherichia coli Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 
2020-05-11 | PXD018789 | Pride
Ac domain translocation Fatty acyl Rtx toxin Acylation Acyltransferase Integrin 
TranscriptomicsDifferential Expression of NF-kB target genes in MALT lymphoma with and without chromosome translocation
MALT lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the NF-κB pathway. Gastric MALT lymphomas harboring such translocation do not respond to H. pylori eradication, while those without translocation can be...
ORGANISM(S): Homo sapiens 
2010-05-31 | E-GEOD-18736 | biostudies-arrayexpress
UnknownMembrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region.
Not available
S-EPMC5705984 | biostudies-literature
TranscriptomicsIdentification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (miRNA)
The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias as well as in lymphoma. We have previously demonstrated that the expression of the human CALM/AF10 fusion gene in murine bone marrow stem and progeni...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-27512 | biostudies-arrayexpress
TranscriptomicsIdentification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (mRNA)
The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias as well as in lymphoma. We have previously demonstrated that the expression of the human CALM/AF10 fusion gene in murine bone marrow stem and progeni...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-27513 | biostudies-arrayexpress
UnknownThe C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus.
Not available
S-EPMC6978384 | biostudies-literature
TranscriptomicsPharmacologic inhibition of STAT5 in AML
The transcription factors STAT5A and STAT5B are essential downstream mediators of many tyrosine kinases, particularly in hematopoietic cancers. As such, STAT5 is activated by FLT3-ITD, which is a constitutively active tyrosine kinase driving the pathogenesis of acute myeloid leukemia (AML). Since ST...
ORGANISM(S): Homo sapiens 
2018-09-03 | GSE103510 | GEO
TranscriptomicsWhole transcriptome analysis of sinonasal sarcoma with translocation t(2;4)(q37.1;q31.3)
Conventioal cytogenetic on 2 sinonasal sarcoma (SNS) cases showed t(2;4)(q37.1;q31.3) translocation previously. The aim of this whole transcriptome analysis is to determine potential candidate genes involved in this translocation. Total RNA extracted from frozen cultured primary tumor cells from a S...
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-52257 | biostudies-arrayexpress
UnknownIncreased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment.
Not available
S-EPMC2913972 | biostudies-literature
UnknownIdentification of a hemerythrin-like domain in a P1B-type transport ATPase.
Not available
S-EPMC2935145 | biostudies-literature
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