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TranscriptomicsGene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples
In this study we conducted transcriptomics analyses of: (i) liver samples from patients suffering from acetaminophen-induced acute liver failure (n=3) and from healthy livers (n=2) and (ii) hepatic cell systems exposed to acetaminophen, including their respective vehicle controls. The investigated i...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-74000 | biostudies-arrayexpress
TranscriptomicsAffect of liver transcriptome by acute acetaminophen exposure [mRNA]
To study the global changes of liver transcriptome after acetaminophen overdose. To study the global changes of transcriptome in the liver after acetaminophen overdose. Eight week old female C57BL/6 mice were fasted for 24 hours prior to a single intraperitoneal injection of 350mg/kg of acetaminoph...
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-42178 | biostudies-arrayexpress
TranscriptomicsAffect of liver transcriptome by acute acetaminophen exposure [miRNA]
To study the global changes of liver transcriptome after acetaminophen overdose. To study the global changes of transcriptome in the liver after acetaminophen overdose. Eight week old female C57BL/6 mice were fasted for 24 hours prior to a single intraperitoneal injection of 350mg/kg of acetaminoph...
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-42181 | biostudies-arrayexpress
GenomicsAcetaminophen
Acetaminophen
PRJNA629821 | ENA
TranscriptomicsDifferential Regulation of Mitogen-Activated Protein Kinases by Acetaminophen in TAMH cells
Acetaminophen (APAP), a widely used analgesic and antipyretic that is considered to be relatively safe at recommended doses, is the leading cause of drug-induced liver failure in the United States. 3M-bM-^@M-^Y-Hydroxyacetanilide (AMAP), a regioisomer of acetaminophen is useful as a comparative too...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-18614 | biostudies-arrayexpress
ModelsReddyhoff2015 - Acetaminophen metabolism and toxicity
Reddyhoff2015 - Acetaminophen metabolism and toxicity This model examines acetaminophen metabolism and related hepatotoxicity. Multiple pathways associated with APAP metabolism has been included in the model. Using numerical, sensitivity and timescale analysis, key parameters invo...
2024-09-02 | BIOMD0000000609 | BioModels
Transcriptomicsp53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo
The goal of the present study was to compare hepatic toxicogenomic signatures across in vitro and in vivo mouse models following exposure to acetaminophen (APAP) or its relatively nontoxic regioisomer 3'-hydroxyacetanilide (AMAP). Two different Affymetrix microarray platforms and one Agilent Oligonu...
ORGANISM(S): Mus musculus 
2016-03-29 | E-GEOD-56576 | biostudies-arrayexpress
ProteomicsBioinformatics and mass spectrometry-based proteomics reveal alcohol dehydrogenase 1B as a blood biomarker candidate to monitor acetaminophen-induced liver injury
Acute liver injury (ALI) is a severe disorder resulting from excessive hepatocyte cell death and frequently caused by acetaminophen intoxication. Clinical management of ALI progression is hampered by the dearth of blood biomarkers available. In this study, a bioinformatics workflow was developed to ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-29 | PXD028082 | Pride
Proteomics  mass spectrometry  liver  blood  biomarker  acetaminophen 
TranscriptomicsTranscription profiling of rat blood and liver exposed to acetaminophen (APAP)
This SuperSeries is composed of the following subset Series:; GSE5593: Acetaminophen (APAP) Rat Blood Training Gene Expression Data Set; GSE5594: Acetaminophen (APAP) Rat Blood Test Gene Expression Data Set; GSE5595: Acetaminophen (APAP) Rat Liver Test Gene Expression Data Set; The Supplementary fil...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5652 | biostudies-arrayexpress
ProteomicsReactive Metabolite-induced Protein Glutathionylation Mechanistically Accounts for Acetaminophen Hepatotoxicity
Although covalent protein binding is established as the pivotal event underpinning acetaminophen (APAP) toxicity, its mechanistic details remain unclear. In this study, we demonstrated that APAP induces widespread protein glutathionylation in a time-, dose- and bioactivation-dependent manner in Hepa...
ORGANISM(S): Homo Sapiens (human) 
2018-09-20 | PXD009986 | JPOST Repository
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