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TranscriptomicsPrimary TNBC tumor in the presence or absence of SHP2
The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix recepto...
ORGANISM(S): Homo sapiens 
2012-01-16 | E-GEOD-35118 | biostudies-arrayexpress
TranscriptomicsBT474 tumors in the presence or absence of SHP2
The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix recepto...
ORGANISM(S): Homo sapiens 
2011-12-20 | E-GEOD-34523 | biostudies-arrayexpress
TranscriptomicsMCF10A cells expressing HER2 and HER3 and grown in three-dimensional cultures
The tyrosine kinase receptors HER2 and HER3 play an important role in breast cancer. The HER2/HER3 heterodimer is a critical oncogenic unit associated with reduced relapse-free and decreased overall survival. We provide gene expression profile of the mammary epithelial cells MCF10A expressing HER2, ...
ORGANISM(S): Homo sapiens 
2012-09-01 | E-GEOD-37009 | biostudies-arrayexpress
TranscriptomicsCirculating Tumor Cell Clusters are Oligoclonal Precursors of Breast Cancer Metastasis
Clusters of circulating tumor cells (CTC-clusters) are present in the blood of patients with cancer but their contribution to metastasis is not well defined. Here, we first use mouse models to demonstrate that breast cancer cells injected intravascularly as clusters are more prone to survive and col...
ORGANISM(S): Homo sapiens 
2014-07-11 | E-GEOD-51827 | biostudies-arrayexpress
TranscriptomicsA microfluidic device for label-free, physical capture of circulating tumor cell-clusters
Cancer cells metastasize through the bloodstream either as single migratory circulating tumor cells (CTCs) or as multicellular groupings (CTC-clusters). Existing technologies for CTC enrichment are designed primarily to isolate single CTCs, and while CTC-clusters are detectable in some cases, their ...
ORGANISM(S): Homo sapiens 
2015-05-17 | E-GEOD-67939 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of ex vivo culture of circulating breast tumor cells
Analyses of circulating tumor cells (CTC) cultured from blood of patients with cancer may allow individualized testing for susceptibility to therapeutic regimens. We established ex vivo cultures of CTCs from six patients with metastatic estrogen receptor-positive breast cancer and performed RNA-Seq...
ORGANISM(S): Homo sapiens 
2014-07-11 | E-GEOD-55807 | biostudies-arrayexpress
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