Acidic ph - OmicsDI

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UNIPROT ID/AC

P01258 (1)
A0A099NRA1 (1)
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A0A099P1L3 (1)
A0A099NY79 (1)
A0A099NX68 (1)
A0A099NZ52 (1)
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CHEBI ID

CHEBI:36916 (1)
CHEBI:72568 (1)
CHEBI:84432 (1)
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CHEBI:13997 (1)
CHEBI:1 (1)
CHEBI:1879 (1)
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CHEBI:52975 (1)
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CHEBI:53038 (1)
CHEBI:17309 (1)
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CHEBI:53034 (1)
CHEBI:60449 (1)
CHEBI:50611 (1)
CHEBI:53033 (1)
CHEBI:53047 (1)

Metabolite Name

Serine (68)
Isoleucine (68)
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5-oxoproline (67)
Tryptophan (67)
Asparagine (67)
Arginine (67)
Alanine (67)
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Uridine (66)
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Citrulline (65)
Allantoin (65)
Fructose (65)
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Modelling Approach

Ordinary differential equation model (5)
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Lab affiliation

University of Victoria (38)
Associate Member, St. Jude Faculty Developmental Neurobiology St. Jude Children's Research Hospital Memphis, TN-38105 (10)
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Institute for Research in Immunology and Cancer, Department of Biochemistry, Department of Chemistry, Université de Montréal, Québec, Canada H3T 1J4 (7)
Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA) (4)
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LSUHSC Proteomics Core Facility Department of Biochemistry and Molecular Biology LSU Health Sciences Center New Orleans, LA 70112 (2)
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Lymphoid Malignancies Branch Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda, Maryland (2)
Soochow University (2)
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Laboratory of Structural Biology and Cell Signaling Institute of Microbiology of the Czech Acad Sci Prumyslova 595 252 50 Vestec Czech Republic (2)
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Technical University of Munich, Department of Chemistry, Chair of Organic Chemistry II, Lichtenbergstraße 4, 85748 Garching, Germany (1)
Centre for Proteome Research Institute of Integrative Biology University of Liverpool Biosciences Building Crown Street Liverpool L69 7ZB UK (1)
Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK (1)
PI (Professor of Cancer Biology) (1)
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Department of Nephrology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China;Guangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases; Guangzhou, China. (1)
Department of Biochemistry The LSUHSC Proteomic Core Facility Louisiana State University Health Sciences Center New Orleans, LA 70112 (1)
National Center for Biotechnology (CNB-CSIC) Darwin,3, 28049 Madrid, Spain (1)
Department of Biochemistry and Molecular Biology Proteomics Core Facility LSUHSC New Orleans,LA 70112 (1)
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Submitter Keywords

FROG (2)

Classification

bacteria (71)
fungi (20)

Modification

-17.026549 (2)
42.010565 (2)
15.994915 (2)
26.01565 (1)
32.056407 (1)
45.029395 (1)
N6 (1)
N6-dimethyl-L-lysine (1)
57.021464 (1)
+3amu) (1)
4-tetrahydrothiazine-3-carboxylic acid (1)
Not available (1)

Study type

ChIP-seq (278)
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RNA-seq of coding RNA (95)
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Other (29)
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Lysine acetyltransferase Rv0998 coordinates transcriptional and metabolic adaptation of Mycobacterium tuberculosis to acidic pH

Mycobacterium tuberculosis (Mtb) survives host defences by adapting to host conditions, including acid stress, during infection. A critical survival strategy involves pH homeostasis, mediated by complex signalling systems that regulate metabolic reprogramming and stress responses. While ...

2026-09-03 | MTBLS15171 | MetaboLights

Mycobacterium tuberculosis transcriptional responses to acidic pH and carbon source

The purpose of this study was to examine how Mtb integrates acidic pH and available carbon sources as environmental cues to regulate its metabolism and growth rate. RNA-seq transcriptional profiling of M. tuberculosis growing at acidic or neutral pH, in pyruvate or glycerol, was examined. These stu...

ORGANISM(S): Mycobacterium tuberculosis

2014-07-07 | E-GEOD-52020 | biostudies-arrayexpress

The pH-sensing receptor OGR1 improves barrier function of CaCo-2 cells and inhibits migration in an acidic environment

OGR1 is a pH-sensing G-protein coupled receptor involved in intestinal homeostasis and inflammation Proton activation of OGR1 increases barrier function in Caco2 cells Microarray profiling was performed on OGR1 stable overexpressing Caco-2 cells during acidic pH shift

ORGANISM(S): Homo sapiens

2015-08-13 | E-GEOD-60294 | biostudies-arrayexpress

Identification of acidic extracellular pH-modulated genes

PRJNA1154953 | ENA

HUVECs with endogenous or overexpressed GPR4 treated with pH 8.4 (control) or pH 6.4 for 5 h

Acidic tissue microenvironment is commonly found in a variety of pathophysiological conditions. GPR4 is a proton-sensing G protein-coupled receptor that is fully activated by acidic extracellular pH but has lesser activity at the physiological pH 7.4 and minimal activity at more alkaline pH. To dete...

ORGANISM(S): Homo sapiens

2013-04-25 | E-GEOD-40060 | biostudies-arrayexpress

Histone acetylation regulates intracellular pH

Differences in global levels of histone acetylation occur in normal and cancer cells, although the reason cells regulate these levels has remained unclear. Here we demonstrate a role for histone acetylation in regulating intracellular pH (pHi). As pHi decreases, histones are globally deacetylated by...

ORGANISM(S): Homo sapiens

2012-11-04 | E-GEOD-40114 | biostudies-arrayexpress

Al-Husari2013 - pH and lactate in tumor

The paper describes a model of pH control in tumor. Created by COPASI 4.26 (Build 213) This model is described in the article: Regulation of tumour intracellular pH: A mathematical model examining the interplay between H and lactate Maymona Al-Husari, Steven D. Webb Journal of Theoretical Biolog...

2024-09-02 | BIOMD0000000805 | BioModels

Effect of pH on Cadmium Toxicity in Escherichia coli

Metals at high concentrations can exert toxic effects on microorganisms. It has been widely reported that lowering environmental pH reduces effects of cadmium toxicity in bacteria. Understanding the effects of pH-mediated cadmium toxicity on bacteria would be useful for minimizing cadmium toxicity...

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655

2008-08-21 | E-GEOD-12373 | biostudies-arrayexpress

The G protein-coupled pH-sensing receptor OGR1 is a regulator of intestinal inflammation

OGR1 is a pH sensing G protein-coupled receptor involved in intestinal homeostasis and inflammation. Up-regulation of genes, mediated by OGR1, in response to extracellular acidification were enriched for inflammation, immune response, actin cytoskeleton and cell adhesion pathways. Microarray profili...

ORGANISM(S): Mus musculus

2015-04-12 | E-GEOD-60295 | biostudies-arrayexpress

Identification of acidic extracellular pH-modulated genes

To investigate the genes that are modulated by acidic extracellular pH, we treated the mouse B16-BL6 cells with acidic medium and then analyzed them comprehensively by cDNA microarray.

ORGANISM(S): Mus musculus

2024-09-09 | GSE276124 | GEO

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