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TranscriptomicsTimecourse total transcriptome sequencing of MCF10A cells undergoing acinus formation.
RNA-seq was performed for transcriptional analysis of MCF10A cells, an epithelial mammary cell line. MCF10A cells were cultured in 3D acinus forming conditions (in Matrigel). Timepoints analysed were 24h, 34h, 36h, 38h and 48h into acinus formation. Control cells were monoloayer.
ORGANISM(S): Homo sapiens 
2014-10-02 | E-MTAB-2969 | biostudies-arrayexpress
ProteomicsQuantitative proteomic comparison between wild type Col and acinus-2 pinin-1 mutant using 15N metabolic labeling
ACINUS and PININ genes regulate transcription and alternative splicing (Bi et al., 2021) and we hypothesize that some proteins should have altered expression in the double mutant. Therefore, MS experiments were designed to identify these altered proteins on a global scale using 15N metabolic labeli...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-04 | PXD030081 | Pride
Arabidopsis Acinus Quantification 15n metabolic labeling Protein prospector Pinin 
ProteomicsUsing targeted quantification (PRM) to quantify proteins between wild type Col and acinus-2 pinin-1 mutant with 15N metabolic labeling
ACINUS and PININ genes regulate transcription and alternative splicing (Bi et al., 2021) and we hypothesize that some proteins should have altered expression in the double mutant. Therefore, MS experiments were designed to identify these altered proteins on a global scale using 15N metabolic labeli...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-04-19 | PXD030096 | Pride
Arabidopsis Acinus Quantification 15n metabolic labeling Protein prospector Targeted quantification Pinin Parallel reaction monitoring (prm) 
GenomicsTimecourse total transcriptome sequencing of MCF10A cells undergoing acinus formation.
Timecourse total transcriptome sequencing of MCF10A cells undergoing acinus formation.
PRJEB7386 | ENA
ProteomicsFunctional proteomics identifies acinus L as a direct insulin- and amino acid-dependent mTORC1 substrate
The serine/threonine kinase mammalian target of rapamycin (mTOR) governs growth, metabolism, and aging in response to insulin and amino acids (aa), and is often activated in metabolic disorders and cancer. Much is known about the regulatory signaling network around mTOR, but surprisingly few direct ...
ORGANISM(S): Homo sapiens (Human) 
2015-04-28 | PXD001245 | Pride
Lc-ms Human Ms-based in vitro kinase assay Mtor 
GenomicsRNA-seq analysis of acinus-2 pnn vs WT Arabidopsis seedlings
RNA-seq analysis of acinus-2 pnn vs WT Arabidopsis seedlings
PRJNA434810 | ENA
Proteomics15N Stable-isotope-labeling in Arabidopsis (SILIA) quantitative MS analysis of the AtACINUS interactome
AtACINUS protein is involved in regulation of alternative transcription and splicing(AS). Identifying interaction partners and protein complex compositions for AtACINUS can produce valuable information on the mechanisms by which they regulate transcription and AS, as well as post-translational modif...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-12-02 | PXD020700 | Pride
Seedling Acinus Plant Arabidopsis thaliana Atacinus Co-immunoprecipitation 15n stable-isotope-labeling in arabidopsis(silia) Ip-ms Lc-ms/ms 
TranscriptomicsThe RNA-binding profile of Acinus, a peripheral component of the Exon junction complex, reveals its role in splicing regulation
Acinus (Apoptotic Chromatin Condensation Inducer in the Nucleus) is an RNA-binding protein (RBP) originally identified for its role in apoptosis. It was later found to be an auxiliary component of the Exon Junction Complex (EJC), which is deposited at exon junctions as a consequence of pre-mRNA spli...
ORGANISM(S): Homo sapiens 
2016-05-26 | GSE81460 | GEO
TranscriptomicsRNA-seq analysis of acinus-2 pnn vs WT Arabidopsis seedlings
RNA-seq analysis of revealed differential expression changes and alternative splicing events in acinus-2 pnn compared to WT
ORGANISM(S): Arabidopsis thaliana 
2020-05-23 | GSE110923 | GEO
UnknownCrystal structure of human Acinus RNA recognition motif domain.
Not available
S-EPMC6057467 | biostudies-literature
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