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TranscriptomicsExamination of gene expression in cerebellum of mouse strains B6J, B6J-nmf205-/-, B6J-Gcn2-/- and B6J-nmf205-/-;Gcn2-/-.
Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathways we analyzed the brain of B6J-nmf205-/- mice in which neuronal elongation complexes are stalled at...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-79929 | biostudies-arrayexpress
TranscriptomicsRibosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration
In higher eukaryotes, the large numbers of nuclear-encoded tRNA genes partially ensure the robustness of cytoplasmic protein translation. Here we discover that a loss-of-function in n-Tr20, a member of the nuclear-encoded tRNA Arg UCU family that is expressed specifically in the central nervous syst...
ORGANISM(S): Mus musculus 
2014-07-28 | E-GEOD-56127 | biostudies-arrayexpress
TranscriptomicsExamination of gene expression in cerebellum and hippocampus for mouse C57BL/6J WT and nmf205-/-
Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathways we analyzed the brain of B6J-nmf205-/- mice in which neuronal elongation complexes are stall...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-79926 | biostudies-arrayexpress
TranscriptomicsSNP data from human fibroblasts and induced Pluripotent Stem cells.
We have generated human induced Pluripotent Stem cells (hiPSc) using Sendai virus-mediated delivery of reprogramming factors. hiPSc lines have been screened using SNP array to assess chromosomal stability (alongside the fibroblast lines from which they derived), and validation of the pluripotency of...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-69287 | biostudies-arrayexpress
TranscriptomicsTranscriptome data from induced Pluripotent Stem cells
We have generated human induced Pluripotent Stem cells (hiPSc) using Sendai virus-mediated delivery of reprogramming factors. hiPSc lines have been screened using SNP array to assess chromosomal stability (alongside the fibroblast lines from which they derived), and validation of the pluripotency of...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-69288 | biostudies-arrayexpress
TranscriptomicsActivation of GCN2 by Ribosome Stalling Links Translation Elongation with Translation Initiation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-79930 | biostudies-arrayexpress
UnknownStaphylococcus aureus α-Toxin Response Distinguishes Respiratory Virus-Methicillin-Resistant S. aureus Coinfection in Children.
Not available
S-EPMC5144732 | biostudies-literature
TranscriptomicsExpression data from primary term human decidual cells treated with interleukin-1-beta for 6 hours.
Preterm birth is an important unsolved clinical problem. Despite advanced treatments, infants who survive prematurity remain at increased risk for permanent disabilities. In approximately one-third of cases, prematurity is related to infection and/or inflammation, which renders hostile the normall...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-58220 | biostudies-arrayexpress
UnknownCopper regulates cyclic-AMP-dependent lipolysis.
Not available
S-EPMC4955676 | biostudies-literature
UnknownCaregivers' and providers' perspectives of social and medical care after pediatric liver transplant: Results from the multicenter SOCIAL-Tx study.
Not available
S-EPMC11176037 | biostudies-literature
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