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SARS-CoV-2 extensively N-glycosylates its spike proteins, which are essential for host cell invasion, target of vaccines, and immunotherapy. These N-glycans are predicted to help mediate spike binding to the host receptor. We investigated the essentiality of the host N-glycosylation pathway and viru...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-02-04 | PXD026431 | Pride
Mouse lung cancers were generated using the KrasLA model, in which a latent mutated Kras2 allele (resulting in the amino acid substitution G12D) is sporadically activated through spontaneous homologous recombination. These mice develop lung adenomas with full penetrance; over time, the tumors acquir...
ORGANISM(S): Mus musculus 
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