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TranscriptomicsTranscription profiling of human normal skin, actinic keratosis and squamous cell carcinoma
normal skin (no), actinic keratosis (ak), and squamous cell carcinoma (scc) of the skin were examined:; BACKGROUND: Carcinogenesis is a multi-step process indicated by several genes up- or down-regulated during tumor progression. This study examined and identified differentially expressed genes in c...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2503 | biostudies-arrayexpress
TranscriptomicsKey differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling
Cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in fair skinned populations worldwide and its incidence is increasing. Despite previous observations of multiple genetic abnormalities in cSCC, the oncogenic process remains elusive. The purpose of this study was to inve...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-45216 | biostudies-arrayexpress
TranscriptomicsSAGE profiles from cultured keratinocytes and human epidermis
SAGE libraries from cultured, differentiated keratinocytes and human epidermis, both normal and affected by actinic keratosis Keywords = Keratinocyte, Epidermis, Homo sapiens, Actinic Keratosis, TNF alpha
ORGANISM(S): Homo sapiens 
2002-02-21 | E-GEOD-31 | biostudies-arrayexpress
TranscriptomicsRNAseq experiment of non-exposed skin, actinic keratosis, intraepidermal carcinoma and squamous cell carcinoma
The goal of the study is to compare the transcriptomic profile of patient-derived skin samples, Actinic Keratosis, Intraepidermal Carcinoma and Squamous Cell Carcinoma samples using next generation RNA Sequencing. We aim to identify perturbed pathways and similarities between the 4 conditions. Pleas...
ORGANISM(S): Homo sapiens 
2017-05-16 | E-MTAB-5678 | biostudies-arrayexpress
ProteomicsDifferential proteomic analysis of actinic keratosis, Bowen's disease and cutaneous squamous cell carcinoma by label-free LC-MS/MS
BACKGROUND: The boundaries between actinic keratosis (AK), Bowen's disease (BD), and cutaneous squamous cell carcinoma (cSCC) are sometimes not clear. Large-scale proteomic profiling studies of these lesions are also non-existent. OBJECTIVE: To evaluate proteomic changes between normal epidermis, A...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD011609 | Pride
Actinic keratosis  bowen’s disease  cutaneous squamous cell carcinoma  mass spectrometry-based proteomics 
ProteomicsProteomic analysis of tape-stripped actininc keratosis
This project aims to evaluates Tape Stripping (TS) of stratum corneum (SC) for non-invasive proteomic analysis of AK using mass spectrometry approach.
ORGANISM(S): Homo sapiens (Human) 
2018-10-01 | PXD011000 | Pride
Tape-stripping Proteomics Actininc keratosis Lc-ms/ms 
TranscriptomicsIngenol mebutate induces profound inflammatory and wound healing responses in uninvolved and actinic keratosis skin
We studied the transcriptomic profile of actinic keratosis (AK) skin compared to matched samples from uninvolved skin (US) before and after treatment with ingenol mebutate gel. We found that AK has a distinct mRNA profile that separates it from uninvolved skin. In particular, numerous genes associat...
ORGANISM(S): Homo sapiens 
2016-03-31 | E-GEOD-63107 | biostudies-arrayexpress
GenomicsTHE GENOMIC LANDSCAPE OF ACTINIC KERATOSIS
Actinic keratoses (AK) are lesions of epidermal keratinocyte dysplasia and are pre-cursor lesions to invasive cutaneous squamous cell carcinoma (cSCC). Identifying the specific genomic alterations driving the progression of normal skin to AK and invasive cSCC is challenging due to the massive, ultra...
EGAS00001004243 | EGA
GenomicsIdentification of differentially expressed genes in actinic keratosis samples treated with ingenol mebutate gel
Identification of differentially expressed genes in actinic keratosis samples treated with ingenol mebutate gel
PRJNA595920 | ENA
TranscriptomicsIdentification of differentially expressed genes in actinic keratosis samples treated with ingenol mebutate gel
Actinic keratosis is a common skin disease that may progress to invasive squamous cell carcinoma. Ingenol mebutate has demonstrated efficacy in field treatment of actinic keratosis. However, molecular mechanisms on ingenol mebutate response are not yet fully understood.
ORGANISM(S): Homo sapiens 
2020-05-18 | GSE142108 | GEO
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