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MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
TranscriptomicsActivating transcription factor 3 regulates immune and metabolic homeostasis
Integration of metabolic, stress and immune responses plays a fundamental role during animal development to maintain energy homeostasis while ensuring growth and proper developmental timing. Perturbation of metabolic and immune signaling circuits has detrimental consequences to animal development in...
ORGANISM(S): Drosophila melanogaster 
2012-11-05 | E-GEOD-36377 | biostudies-arrayexpress
MetabolomicsActivated ATF6α is a hepatic tumor driver restricting immunosurveillance

Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality with limited therapies. While endoplasmic reticulum (ER)-stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR-transducer activating transcription factor 6 alpha (ATF...

2025-11-17 | MTBLS13241 | MetaboLights
TranscriptomicsComparison of the expression profiles of wild type (WT) and Oct-6-deficient (Oct-6-/-) macrophages in response to poly(I:C) treatment
Identification of target genes of the POU-transcription factor Oct-6 in macrophages after poly(I:C) treatment WT and Oct-6-/- fetal-liver macrophages were treated with poly(I:C) for 8 hours or were left untreated (3 independent expreiments = biological replicates). 200 genes differentially regulated...
ORGANISM(S): Mus musculus 
2010-08-01 | E-GEOD-22691 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adult primary neural stem cells when stimulated with the proliferative agent PACAP (pituitary adenylate cyclase-activating polypeptide)
Investigation of transcriptional changes induced in adult primary neural stem cells when stimulated with the proliferative agent PACAP (pituitary adenylate cyclase-activating polypeptide). In addition the data was compared to results obtained from a proliferation control (stimulation with a transmem...
ORGANISM(S): Mus musculus 
2005-05-15 | E-MEXP-322 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood monocytes treated with simvastatin reveals it has an anti-inflammatory effect on macrophages via upregulation of Kruppel-like factor-2
HMG-CoA reductase inhibitors, statins, have beneficial vascular effects beyond their cholesterol-lowering action. These pleiotropic effects include an anti-inflammatory effect on macrophages. Since macrophages play a central role in atherogenesis, we further characterized the effects on peripheral b...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4883 | biostudies-arrayexpress
GenomicsIdentification of transcription factor Srf binding sites and histone 3 actetylated regions in mouse cardiomyocytes
We investigated the cardiac transcription network driven by the DNA-binding key factor Srf in combination with epigenetic marks of histone 3 acetylation (H3ac). Srf has been shown to play a key role in cardiac cell growth and muscle gene regulation. However, we still have limited understanding of th...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-19065 | biostudies-arrayexpress
Models,MultiomicsCell Cycle Transcription by Coupled CDK and Network Oscillators
A significant fraction of the Saccharomyces cerevisiae genome is transcribed periodically during the cell division cycle, indicating that properly timed gene expression is important for regulating cell-cycle events. Genomic analyses of the localization and expression dynamics of transcription factor...
2681 | Cell Collective
GenomicsTranscription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells
This SuperSeries is composed of the following subset Series: GSE35910: Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells [EBF1] GSE35914: Transcription factor Ebf1 regulates differentiation stage-specific signaling, prolifer...
ORGANISM(S): Mus musculus 
2012-04-02 | E-GEOD-35915 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast mutants sep10 and sep15
The fission yeast Mcs6-Mcs2-Pmh1 complex (homologous to metazoan Cdk7-cyclin HMat1) performs dual functions: in cell cycle control, as a CDK-activating kinase; and in transcription by RNA polymerase (Pol) II, as part of TFIIH. It is unknown whether that linkage serves to coordinate gene expression w...
ORGANISM(S): Schizosaccharomyces pombe 
2004-11-01 | E-MEXP-193 | biostudies-arrayexpress
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