Sort   by:  
 Page size 
ProteomicsActive kinome in human skeletal muscle insulin resistance
Obesity-related insulin resistance (OIR) is one of the main contributors to type 2 diabetes and other metabolic diseases. Protein kinases are implicated in key signaling steps including insulin signaling and glucose metabolism. Molecular mechanisms underlying OIR involving global active kinases rema...
ORGANISM(S): Homo sapiens (Human) 
2020-01-23 | PXD011909 | Pride
Quantitative proteomics Protein kinase Human skeletal muscle Insulin resistance Active kinome 
ProteomicsCharacterisation of the Active Kinome of Leishmania
Background: Leishmania parasites cause neglected tropical diseases such as cutaneous and visceral leishmaniasis, which have limited treatment options and rising drug resistance. Protein kinases are pivotal in Leishmania biology and attractive drug targets, but their functional status in the parasite...
ORGANISM(S): Leishmania mexicana 
2025-12-18 | PXD066933 | Pride
Parasite Drug target Leishmania Chemoproteomics Neglected tropical disease Activity-based protein profiling Protein kinase Kinome 
UnknownActivity-based chemoproteomic profiling reveals the active kinome of <i>Leishmania</i>.
Not available
S-EPMC12816314 | biostudies-literature
UnknownKinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases.
Not available
S-EPMC7698519 | biostudies-literature
ProteomicsQuantitative analysis of the erythrocyte kinome
The erythrocytes, the most numerous cells of the human body (Sender 2016), have the fundamental function of providing oxygen to the other cells throughout the organism. Protein phosphorylations are involved in the regulation of several important mechanisms in erythrocytes, such as cytoskeleton remod...
ORGANISM(S): Homo sapiens (Human) 
2018-09-18 | PXD009396 | Pride
Erythrocytes Red blood cells Kinome Kinases Label free quantification Human primary cells 
ProteomicsKinome-profiling enabled discovery of a LATS1/2 inhibitor with wound healing potential
System-level mapping of kinase inhibitors polypharmacology can uncover opportunities for drug repurposing and identify starting points for medicinal chemistry campaigns aimed at novel targets. Here, we describe a large-scale profiling of 257 kinase inhibitors that revealed domains of promiscuity, po...
ORGANISM(S): Homo sapiens (Human) 
2026-07-15 | PXD073488 | Pride
Human Proteomics Kinase selectivity profiling Kinase inhibitor 
UnknownThe Exploration of Chirality for Improved Druggability within the Human Kinome.
Not available
S-EPMC10536157 | biostudies-literature
UnknownSrc signaling in a low-complexity unicellular kinome.
Not available
S-EPMC5876402 | biostudies-literature
UnknownKinomeMETA: a web platform for kinome-wide polypharmacology profiling with meta-learning.
Not available
S-EPMC11223815 | biostudies-literature
UnknownDocking-Informed Machine Learning for Kinome-wide Affinity Prediction.
Not available
S-EPMC11684025 | biostudies-literature
Sort   by:  
 Page size