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GenomicsGraded Nodal/Activin Signaling Governs ES Cell Fate Decisions via Differential Recruitment of Phospho-Smad2 to Oct4 and Distinct Target Gene Subsets.
The Nodal/Activin morphogens are secreted signaling molecules that form concentration gradients during early embryogenesis providing stem cells with positional information and differentiation instructions important for embryonic patterning. The molecular basis driving stem cell interpretation of sig...
ORGANISM(S): Mus musculus 
2011-01-31 | E-GEOD-23581 | biostudies-arrayexpress
GenomicsActivin/Nodal signalling controls divergent transcriptional networks in pluripotent and endoderm progenitors.
Activin/Nodal signalling is necessary to maintain pluripotency of human Embryonic Stem Cells (hESCs) and to induce their differentiation towards endoderm. However, the mechanisms by which Activin/Nodal signalling achieves these opposite functions remain unclear. To unravel these mechanisms, we exami...
ORGANISM(S): Homo sapiens 
2011-11-11 | E-GEOD-19461 | biostudies-arrayexpress
TranscriptomicsmicroRNA and mRNA expression profiles of human embryonic stem cells treated with activin A
Human embryonic stem (hES) cells have the capacities to propagate for extended periods and to differentiate into cell types from all three germ layers both in vitro and in vivo. These characteristics of self-renewal and pluripotency enable hES cells having the potential to provide an unlimited suppl...
ORGANISM(S): Homo sapiens 
2010-09-10 | E-GEOD-16910 | biostudies-arrayexpress
TranscriptomicsVallier D4.5 SB
Gene expression profiling experiment to identify genes up and down regulated by the presence of Activin during pancreatic specification.
ORGANISM(S): Homo sapiens 
2011-11-12 | E-MTAB-606 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic stems cells grown in chemically defined medium supplemented with Activen and FGF or FGF2 and SB431542 to identify genes controlled by Activin/Nodal signalling
Human Embryonic Stem Cells (hESC) grown in chemically defined medium (CDM) supplemented with Activin and FGF were compared to hESCs grown for 48 hours in CDM supplemented with FGF2 and SB431542, an inhibitor of Activin/Nodal signalling. The objective of this experiment was to discover the identity o...
ORGANISM(S): Homo sapiens 
2009-03-14 | E-MEXP-1741 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of skeletal muscles treated with a soluble activin type IIB receptor
Inhibition of the myostatin signaling pathway is emerging as a promising therapeutic means to treat muscle wasting disorders. Activin type IIB receptor is the putative myostatin receptor, and a soluble activin receptor (ActRIIB-Fc) has been demonstrated to potently inhibit a subset of TGF-β family m...
ORGANISM(S): Mus musculus 
2011-02-04 | E-GEOD-25306 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Activin-like kinase 2 knockout in mice
Implantation of an embryo in the uterus is a multistep process tightly controlled by an intricate regulatory network of interconnected ovarian, uterine, and embryonic factors. Bone morphogenetic protein (BMP) ligands and receptors are expressed in the pregnant uterus, and BMP2 has been shown to be a...
ORGANISM(S): Mus musculus 
2014-01-07 | E-GEOD-46689 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stell cells to investigate Activin/Nodal signaling
Members of the transforming growth factor (TGF)-β superfamily play essential roles in the pluripotency, self-renewal, and differentiation of embryonic stem cells. While bone morphogenic proteins maintain pluripotency of undifferentiated mouse ES cells, the role of Activin/Nodal signaling is less cl...
ORGANISM(S): Mus musculus 
2009-09-12 | E-GEOD-17879 | biostudies-arrayexpress
TranscriptomicsActivin regulates H3K4me3 in hPSC
Activin signalling controls the pluripotency of human embryonic stem cells (hESCs) by inducing the formation of nuclear Smad2/3-Nanog complexes that bind to and regulate several downstream targets. We aimed to clarify the transcriptional dynamics to the inhibition of Activin in hPSCs. To this end we...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-MTAB-2749 | biostudies-arrayexpress
ProteomicsActivin A and NK cell function
Natural killer (NK) cells are innate lymphocytes that play a major role in immunosurveillance against tumor initiation and metastasis spread. Signals and checkpoints that regulate NK cell fitness and function in the tumor microenvironment are not well defined. Transforming grow factor (TGF)- is a re...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-06 | PXD011672 | Pride
Activin signaling Qtof Label-free proteomics Tgf-b signaling 
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