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MetabolomicsIntegrated Multi-omics Analysis Identifies Diagnostic Biomarkers for Acute Coronary Syndrome in Type 2 Diabetes Mellitus Patients

Biomarkers for the early identification of acute coronary syndrome (ACS) risk remain inadequately investigated, particularly in patients with type 2 diabetes mellitus (T2DM), for whom timely clinical intervention may substantially enhance prognostic outcomes. The gut microbiota and serum metaboli...

2026-03-19 | MTBLS14087 | MetaboLights
ProteomicsUrinary metabolomics analysis based on LC-MS for diagnosis and monitoring of Acute coronary syndrome
Acute coronary syndrome (ACS) is a kind of cardiovascular disease caused by acute myocardial ischemia. The aim of this study was to use urine metabolomics to explore the potential biomarkers for the diagnosis of ACS and the changes in metabolites during the development of the disease.
ORGANISM(S): Homo Sapiens 
2024-12-03 | PXD058501 |
ProteomicsComparative platelet releasate proteome profiling of acute coronary syndrome versus stable coronary artery disease
Upon activation, platelets release a host of soluble and vesicular signals, collectively termed the ‘platelet releasate’ (PR). The contents of this PR play a significant role in haemostasis, inflammation, and pathologic sequelae. Despite this, proteomic studies investigating the PR in coronary arter...
ORGANISM(S): Homo sapiens (Human) 
2020-06-05 | PXD009356 | Pride
Platelet releasate Proteomics Platelets Acute coronary syndrome Stable coronary artery disease Lc-ms/ms 
MetabolomicsNMR-based metabolomics identifies patients at high risk of death within two years after acute myocardial infarction in the AMI-Florence II cohort
Risk stratification and management of acute myocardial infarction patients continue to be challenging despite considerable efforts made in the last decades by many clinicians and researchers. The aim of this study was to investigate the metabolomic fingerprint of acute myocardial infarction using nu...
2018-10-02 | MTBLS395 | MetaboLights
MetabolomicsOral-gut microbiome and plasma metabolome reveal incremental restratification of coronary artery disease from the clinical gray zone
Clinical prediction models have been widely applied for risk stratification of coronary artery disease (CAD), yet approximately 20% to 40% of screened individuals fall into the intermediate-risk interval and face a decision gap. Here, we adopted a two-stage validation design. In the first stage, a c...
2026-08-31 | MTBLS15425 | MetaboLights
TranscriptomicsTranscription profiling of human coronary arteries from patients with and without collateral artery vessels to identify novel markers of coronary collateralization
Evaluation of transcriptional regulation in Coronary artery disease patients with and without collateral artery vessels.
ORGANISM(S): Homo sapiens 
2006-03-10 | E-MEXP-564 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in thrombus-derived white blood cells of patients with acute coronary syndrome
Inflammatory mechanisms and immune cells are involved in acute coronary syndromes (ACS) and may lead to acute plaque rupture. However, the local expression of the different genes potentially involved is largely unknown. We therefore performed an Affymetrix analysis of genes expressed in white blood ...
ORGANISM(S): Homo sapiens 
2011-12-04 | E-GEOD-19339 | biostudies-arrayexpress
TranscriptomicsExtracellular Vesicles in acute coronary syndrome: carrier of epigenetics marks
Background: Acute coronary syndromes (ACS) are associated with aberrant gene expression and epigenetic mechanisms. In particular, de novo DNA methylation is typically linked to gene silencing, but its role in heart disease remains not fully understood. Extracellular vesicles (EVs) are active compon...
ORGANISM(S): Homo sapiens 
2023-04-03 | E-MTAB-11641 | biostudies-arrayexpress
UnknownObjectives and Design of the Russian Acute Coronary Syndrome Registry (RusACSR).
Not available
S-EPMC6490746 | biostudies-literature
TranscriptomicsDifferent gene expression profile in acute coronary sindrome (ACS) patients compared to stable angina(SA) patients.
We have employed whole genome microarray expression profiling as a discovery platform to identify genes involved in plaque rupture. Human coronary artery endothelial cells (ECs) were stimulated in vitro for 12 hours with plasma obtained from the coronary sinus (CS) and the aorta (Ao) of patients wit...
ORGANISM(S): Homo sapiens 
2014-02-14 | E-GEOD-54977 | biostudies-arrayexpress
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