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MetabolomicsAnalysis of human urine reveals metabolic changes related to the development of acute kidney injury following cardiac surgery
In an effort to identify novel biomarkers capable of predicting the development of acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB) use, urine specimens were collected before and at 4 and 24 hours after surgery from 106 patients and analyzed by means of nuclear magne...
2012-10-21 | MTBLS24 | MetaboLights
MetabolomicsMicrobial tryptophan metabolism orchestrated by trilobatin through TPH1 activation protects against acute kidney injury
Background: Acute kidney injury (AKI) remains a major clinical challenge with limited therapeutic options. Gut microbiota dysbiosis plays a crucial role in the pathogenesis of AKI. Trilobatin (TLB), has been previously reported to modulate gut microbiota and exert neuroprotective effects; however, i...
2026-04-05 | MTBLS14222 | MetaboLights
MetabolomicsInulin gel-mediated delivery of Clostridium butyricum spores protects against acute kidney injury via regulation of ER-mitochondria contacts
Acute kidney injury (AKI) progression is closely associated with gut microbiota dysbiosis. However, the detailed mechanism remains unclear. In this study, we found that patients with AKI had decreased beneficial bacteria and reduced butyric acid levels in the intestine. Furthermore, butyrate allevia...
2026-09-17 | MTBLS15607 | MetaboLights
MetabolomicsPreterm Neonatal Urinary Renal Developmental and acute kidney injury Metabolomic Profiling
Not available
ORGANISM(S): Homo sapiens 
ST000050 | MetabolomicsWorkbench
MetabolomicsEpimedium-Derived Extracellular Vesicles Alleviate Cisplatin-induced Acute Kidney Injury: Integrated Multi-Omics Analysis and Molecular Simulations Reveal Flavonoid Interactions with PPARα
This study explores the protective effects and potential underlying mechanisms of Epimedium-derived extracellular vesicles (EpEVs) against cisplatin-induced acute kidney injury (CIAKI) in mice. EpEVs were isolated and purified via differential centrifugation combined with sucrose and iodixanol gradi...
2026-09-02 | MTBLS15534 | MetaboLights
TranscriptomicsTranscription profiling of molecular phenotypes of acute kidney injury in kidney transplants
Microarray analysis of human kidneys with acute kidney injury (AKI) has been limited because such kidneys are seldom biopsied. However, all kidney transplants experience AKI, and early kidney transplants without rejection are an excellent model for human AKI: they are screened to exclude chronic kid...
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-30718 | biostudies-arrayexpress
ProteomicsFibroblast-derived Smoothened governs prognosis of acute kidney injury
Although the tubule is the epicenter of damage, kidney fibroblast is increasingly appreciated in governing the prognosis of acute kidney injury (AKI). Smoothened (Smo), a heptahelical transmembrane protein, carries a hedgehog signal to mediate the communications between kidney fibroblasts and tubula...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-23 | MSV000088609 | MassIVE
ProteomicsData-Independent Acquisitions Uncover Kidney Proteome Remodeling during Ischemic Reperfusion Kidney Injury using a Fast-scanning ZenoTOF 7600
Acute kidney injury (AKI) manifests as a major health concern particularly for the elderly and understanding related proteome changes is critical for prevention and development of novel therapeutics to recover kidney function, and to mitigate the susceptibility for recurrent AKI, or development of c...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-11-23 | MSV000090777 | MassIVE
MetabolomicsLung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion
Not available
ORGANISM(S): Mus musculus 
ST001747 | MetabolomicsWorkbench
TranscriptomicsGene expression in post cardiac surgery acute kidney injury
To determine the changes in intra-renal gene expression in a novel large animal model of post Cardiopulmonary Bypass (CPB) acute kidney injury, we collected renal medulla samples obtained 24hours post intervention. The transcriptional profile of the mRNA in these samples was measured with gene array...
ORGANISM(S): Sus scrofa 
2014-09-29 | E-GEOD-44782 | biostudies-arrayexpress
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