Metabolomics

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Preterm Neonatal Urinary Renal Developmental and acute kidney injury Metabolomic Profiling


ABSTRACT: Brophy and Askenazi hypothesize that postnatal renal maturation results in specific identifiable patterns of urinary metabolites and that these profiles will be altered in the presence of AKI. Their long-term goal is to identify novel metabolomics urinary profiles that can provide real-time evidence of evolving neonatal renal injury thereby allowing earlier diagnosis and treatment.This study includes 40 pre-term infants age 2 days. Twenty infants were identified as not having AKI (11 females, mean gestational age=182.8 days, mean birth weight=834.0 grams) and 20 infants were identified as having AKI (13 females, mean gestational age=183.9 days, mean birth weight=815.8 grams). There are no statistical differences between the two groups based on gender, gestational age, and birth weight.

INSTRUMENT(S): FT-NMR

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Urine

DISEASE(S): Kidney Disease

SUBMITTER: Susan Sumner  

PROVIDER: ST000050 | MetabolomicsWorkbench | Wed Apr 30 00:00:00 BST 2014

REPOSITORIES: MetabolomicsWorkbench

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