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MetabolomicsExplore changes of riboflavin metabolism in acute pancreatitis

Gut barrier dysfunction is critical in the pathogenesis of acute pancreatitis (AP), yet the underlying mechanisms remain unclear. Mucin 2 (MUC2), the primary component of the intestinal mucus layer, is essential for gut homeostasis and microbial eubiosis. This study aimed to elucidate the protec...

2025-09-11 | MTBLS12981 | MetaboLights
MetabolomicsGut microbiota-derived deoxycholic acid promotes pancreatic regeneration following acute pancreatitis via Reg3a signaling pathway

Recovery from acute pancreatitis (AP) involves complex biological processes, and the mechanisms governing pancreatic repair remain unclear. In a clinical cohort during the recovery phase of AP, impaired pancreatic recovery was associated with intestinal dysbiosis, depletion of the microbial bile ...

2026-03-08 | MTBLS14000 | MetaboLights
TranscriptomicsmRNA expression pattern of KrasG12D mice with acute pancreatitis compared with wild-type mice without acute pancreatitis
Transgenic KrasG12D mice can recapitulate pancreas intra-epithelial neoplasia (PanIN). Caerulein is a cholecystokinin analogue and induces acute pancreatitis when injected intra-abdominally. Caerulein-induced acute pancreatitis will accelerate PanIN progression in KrasG12D mice. We compared mRNA pro...
ORGANISM(S): Mus musculus 
2016-05-14 | E-GEOD-77983 | biostudies-arrayexpress
MetabolomicsGut Microbiota-Derived Riboflavin Mediates Protective Effects of MUC2 in Acute Pancreatitis via CD40-Macrophage Pathway

Gut barrier dysfunction is critical in the pathogenesis of acute pancreatitis (AP), yet the underlying mechanisms remain unclear. Mucin 2 (MUC2), the primary component of the intestinal mucus layer, is essential for gut homeostasis and microbial eubiosis. This study aimed to elucidate the protect...

2025-09-05 | MTBLS12943 | MetaboLights
MetabolomicsSynbiotic microcapsules delivering Lactiplantibacillus Plantarum AR113 protect against acute pancreatitis via acetate-mediated modulation of the gut-pancreas axis
AM-AR113 protects against AP by improving gut microbial composition, enhancing microbial acetate production, promoting intestinal barrier integrity, and suppressing pancreatic M1 macrophage polarization.
2026-03-26 | MTBLS14147 | MetaboLights
MetabolomicsMetabolic profiling of induced acute pancreatitis and pancreatic cancer progression in a mutant Kras mouse model
Not available
ORGANISM(S): Mus musculus 
ST002202 | MetabolomicsWorkbench
TranscriptomicsTranscriptome profiling of the pancreas samples from animals showing autoimmune pancreatitis and chronic pancreatitis
Autoimmune pancreatitis (AIP) is a disease with unclear immunologic triggers. This study shows that the pancreatic stellate cells are involved in the regulation of the immune response and can cause autoimmunity when the NF-κB signalling in these cells is disrupted.
ORGANISM(S): Mus musculus 
2022-03-31 | E-MTAB-7274 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of pancreatic tissue from wt, KrasG12D, Pi3kCAH1047R and Mek1dd mice, at 10 weeks and after induction of acute pancreatitis
To investigate the underlying changes during acinar-to-ductal metaplasia induced by different oncogenes and by acute pancreatitis, pancreatic tissue was isolated from 10 week old control wt, KrasG12D, Pi3kCAH1047R and Mek1dd mice and from mice of the same genotypes after induction of acute pancreati...
ORGANISM(S): Mus musculus 
2024-04-06 | E-MTAB-13946 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pancreas from patients with autoimmune pancreatitis and alcohol-induced chronic pancreatitis
Autoimmune pancreatitis (AIP) is a recently identified disease of the pancreas with unknown etiology and antigens. The aim of this study was to determine new target antigens and differentially regulated genes and proteins by means of transcriptomics and proteomics and to validate them in patients wi...
ORGANISM(S): Homo sapiens 
2008-12-31 | E-MEXP-804 | biostudies-arrayexpress
ProteomicsProteomic analysis of acute pancreatitis in TRP14-KO miceProteomic analysis of acute pancreatitis in TRP14-KO mice
We have studied pancreas samples in pancreas from a mouse model of acute pancreatitis, comparing wild-type animals and TRP14 KO animals. Samples are extracted with N-ethylmaleimide to block reduced cysteines, and no reducing agent is used, with a search including cysteinylated peptides. Acute pancr...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-15 | PXD050765 | Pride
Mouse model Cysteine Disulfide exchange Pancreatitis Biological redox systems Oxidative stress 
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