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MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
MetabolomicsCars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2.
Targeting transcriptional regulatory complexes represents a promising strategy for activating thermogenic fat and treating obesity. In this study, we focused on identifying critical, specific metabolic pathways enriched during brown adipocyte differentiation. Through analysis of metabolomics and RNA...
2026-03-24 | MTBLS12237 | MetaboLights
MetabolomicsGlutathione is a host-derived cysteine source for Clostridioides difficile
Clostridioides difficile is the leading cause of nosocomial diarrhea, afflicting approximately half a million people each year in the USA, burdening both individuals’ quality of life and the healthcare system. In the gastrointestinal (GI) tract, C. difficile must acquire essential nutrients to colon...
2026-06-10 | MTBLS14740 | MetaboLights
MetabolomicsCarS2-mediated cysteine catabolism drives brown fat development and thermogenesis through persulfidating EBF2
Targeting transcriptional regulatory complexes is a promising strategy to activate thermogenic fat and treat obesity. In this study, we focused on identifying critical and specific metabolic pathways enriched during brown adipocyte differentiation. By analyzing metabolomics and RNA sequencing result...
2026-03-24 | MTBLS12234 | MetaboLights
MetabolomicsIsotope Labeled Reactivity-Based Metabolomics Reveal Cysteine as a Potent In Vivo Scavenger of Lactoylglutathione

Metabolite adducts are increasingly being recognized as important intermediates in cellular metabolism and as circulating messengers. Methylglyoxal (MG) is a highly reactive metabolite involved in diabetes and aging, via formation of a wide variety of protein adducts. Though new types of protein ...

2025-04-29 | MTBLS6287 | MetaboLights
TranscriptomicsAn O-acetylserine(thiol)lyase homolog regulates cysteine homeostasis in Arabidopsis thaliana
Cysteine occupies a central position in plant metabolism due to its biochemical functions. Arabidopsis thaliana cells contain different O-acetylserine(thiol)lyase (OASTL) enzymes that catalyze the biosynthesis of cysteine. Because they are localized in the cytosol, plastids and mitochondria, this re...
ORGANISM(S): Arabidopsis thaliana 
2011-11-23 | E-GEOD-19244 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human liver cell line after cysteine deprivation
First experiment: Cells were cultured in sulfur amino acid-free DMEM supplemented with 0.1 mM methionine + 0.1 mM cysteine (complete) or supplemented only with 0.1 mM methionine (cysteine-free). Cells were cultured in either medium for 42 h (Long + Cys; Long -Cys) or in cysteine-free medium for 36 ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9517 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human N-Acetyl L-cysteine induced differentiation of NHEK cells in vitro
Gene expression analysis of N-Acetyl L-cysteine induced differentiation of NHEK cells in vitro.
ORGANISM(S): Homo sapiens 
2005-11-30 | E-MEXP-500 | biostudies-arrayexpress
ProteomicsSupporting information for tryptic EPO glycopeptide LC-MS analysis via cysteine aminoethylation
Supplementary information for a technical note describing the application of cysteine aminoethylation for the site-specific glycosylation analysis of recombinant human EPO using trypsin as sole protease.
ORGANISM(S): Cho Cells 
2020-04-21 | MSV000085318 | MassIVE
TranscriptomicsClostridium difficile CD630E: growth with 10 mM cysteine in PY vs growth in PY
Comparison of Clostridium difficile transcriptome of strain CD630E grown for 10 hours in PY (supplemented with mild concentration of cysteine) versus PYC (PY supplemented with 10 mM of cysteine). Experimental procedure was designed to investigate the influence of cysteine on toxins production and th...
ORGANISM(S): [Clostridium] difficile 
2013-12-31 | E-GEOD-22423 | biostudies-arrayexpress
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