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TranscriptomicsMolecular heterogeneity in acute renal allograft rejection
The data set contains 67 array (lymphochip cDNA array), published in N Engl J Med 2003 Jul 10;349(2):125-38. PMID: 12853585. TITLE: Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. BACKGROUND: The causes and clinical course of acute rejection vary, a...
ORGANISM(S): Homo sapiens 
2003-07-01 | E-GEOD-343 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bronchoalveolar lavage samples collected from lung transplant recipients with rejection states determined at the time of sample collection
Bronchoalveolar lavage samples collected from lung transplant recipients. Numeric portion of sample name is an arbitrary patient ID and AxBx number indicates the perivascular (A) and bronchiolar (B) scores from biopsies collected on the same day as the BAL fluid was collected. Several patients hav...
ORGANISM(S): Homo sapiens 
2007-08-29 | E-GEOD-2018 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse broncheolar lavage cells to diagnoses of acute lung rejection by gene expression profiling
Acute lung rejection is a risk factor for chronic rejection, jeopardizing the long-term survival of lung transplant recipients. At present, acute rejection is diagnosed by transbronchial lung biopsies, which are invasive, expensive, and subject to significant sampling error. In this study, we sought...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6095 | biostudies-arrayexpress
TranscriptomicsKidney transplantation
In this study, we examined transcriptional profiles from 3 different microarray platforms, across 103 peripheral blood samples with and without acute rejection, to find a critical gene-set for the diagnosis of acute renal rejection that matched biopsy diagnosis, irrespective of patient demographics,...
ORGANISM(S): Homo sapiens 
2012-12-26 | E-GEOD-14067 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peripheral blood lymphocytes (PBL) from four pediatric renal allograft recipients with acute rejection and concurrent anemia
Compromised renal function after renal allograft transplantation often results in anemia in the recipient. Molecular mechanisms leading to anemia during acute rejection are not fully understood; inadequate erythropoietin production and iron deficiency have been reported to be the main contributors. ...
ORGANISM(S): Homo sapiens 
2005-11-01 | E-SMDB-2730 | biostudies-arrayexpress
TranscriptomicsImpact of Animal Strain on Gene Expression in a Rat Model of Acute Cardiac Rejection
The expression levels of many genes show wide natural variation among strains or populations. This study investigated the potential for animal strain-related genotypic differences to confound gene expression profiles in acute cellular rejection (ACR). Additional analysis allowed for selection of 49 ...
ORGANISM(S): Rattus norvegicus 
2010-05-01 | E-GEOD-6342 | biostudies-arrayexpress
TranscriptomicsA peripheral blood diagnostic test for acute rejection in renal transplantation.
In this study, we examined transcriptional profiles from 3 different microarray platforms, across 103 peripheral blood samples with and without acute rejection, to find a critical gene-set for the diagnosis of acute renal rejection that matched biopsy diagnosis, irrespective of patient demographics,...
ORGANISM(S): Homo sapiens 
2012-12-26 | E-GEOD-14346 | biostudies-arrayexpress
TranscriptomicsMyocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection
Aims. Serial invasive endomyocardial biopsies (EMB) remain the gold standard for acute cellular rejection (ACR) diagnosis. However histological grading has several limitations. We aimed to explore the value of myocardial Gene Expression Profiling (GEP) for diagnosing and identifying predictive bioma...
ORGANISM(S): Homo sapiens 
2017-03-07 | E-MTAB-5136 | biostudies-arrayexpress
TranscriptomicsKidney transplantation (SMD set)
In this study, we examined transcriptional profiles from 3 different microarray platforms, across 103 peripheral blood samples with and without acute rejection, to find a critical gene-set for the diagnosis of acute renal rejection that matched biopsy diagnosis, irrespective of patient demographics,...
ORGANISM(S): Homo sapiens 
2012-12-26 | E-GEOD-14357 | biostudies-arrayexpress
TranscriptomicsKidney Transplant Rejection and Tissue Injury by Gene Profiling of Biopsies and Peripheral Blood Lymphocytes
We used DNA microarrays (HG-U95Av2 GeneChips) to determine gene expression profiles for kidney biopsies and peripheral blood lymphocytes (PBLs) in transplant patients. Sample classes include kidney biopsies and PBLs from patients with 1) healthy normal donor kidneys, 2) well-functioning transplants ...
ORGANISM(S): Homo sapiens 
2004-07-14 | E-GEOD-1563 | biostudies-arrayexpress
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